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Biblioteca di genere

biblioteca

 

 

La crescente consapevolezza delle differenze associate al genere e la volontà di garantire ad ogni persona la migliore cura nell’ottica della centralità del paziente e della personalizzazione delle terapie ha condotto all’approvazione, nel giugno 2019, del decreto con cui viene adottato il Piano per l’applicazione e la diffusione della Medicina di Genere previsto dall’articolo 3 della Legge 3/2018. Il GISEG ha fortemente sentito l’esigenza di creare uno strumento per consentire un aggiornamento costante e continuo in salute e Medicina di genere a chiunque sia interessato. Per tale motivo è nata l’idea della biblioteca multimediale. La novità è non solo nella creazione, ma anche nella possibilità di immediata consultazione ed accessibilità a tutti, anche ai “non addetti ai lavori”. Si può quindi, con estrema facilità, consultare l’ampia raccolta di documenti scientifici in ottica di genere che sono stati catalogati per argomenti ed apparati. La biblioteca multimediale è agli albori e, dato anche il crescente interesse della letteratura scientifica per tale argomento, necessita di una continua e costante implementazione, pertanto chiunque voglia contribuire alla crescita di questo archivio può inviare materiale al seguente indirizzo: imma-ambrosino@libero.it

Apparato Cardiovascolare

Aritmie e Fibrillazione Atriale

Marzona I, Proietti M, Vannini T, et al. Sex-related differences in prevalence, treatment and outcomes in patients with atrial fibrillation. Intern Emerg Med. 2020;15(2):231-240. doi:10.1007/s11739-019-02134-z

Tian XT, Xu YJ, Yang YQ. Gender Differences in Arrhythmias: Focused on Atrial Fibrillation. J Cardiovasc Transl Res. 2020;13(1):85-96. doi:10.1007/s12265-019-09918-w

Antonio González-Hermosillo J, Baños-González MA, Guevara-Valdivia ME, et al. Gender differences and management of stroke risk of nonvalvular atrial fibrillation in an upper middle-income country: Insights from the CARMEN-AF registry. IJC Hear Vasc. 2019;22:117-122. doi:10.1016/j.ijcha.2018.12.017

Coleman CI, Turpie AGG, Bunz TJ, Eriksson D, Sood NA, Baker WL. Effectiveness and safety of rivaroxaban vs. warfarin in non-valvular atrial fibrillation patients with a non-sex-related CHA2DS2-VASc score of 1. Eur Hear J - Cardiovasc Pharmacother. 2019;5(2):64-69. doi:10.1093/ehjcvp/pvy025

Ikemura N, Kohsaka S, Kimura T, et al. Assessment of Sex Differences in the Initial Symptom Burden, Applied Treatment Strategy, and Quality of Life in Japanese Patients With Atrial Fibrillation. JAMA Netw open. 2019;2(3):e191145. doi:10.1001/jamanetworkopen.2019.1145

Cheung JW, Cheng EP, Wu , Xian, et al. Sex-based differences in outcomes, 30-day readmissions, and costs following catheter ablation of atrial fibrillation: the United States Nationwide Readmissions Database 2010–14. Eur Heart J. 2019;40(36):3035-3043. doi:10.1093/eurheartj/ehz151

Penttilä T, Lehto M, Niiranen J, et al. Differences in the risk of stroke, bleeding events, and mortality between female and male patients with atrial fibrillation during warfarin therapy. Eur Hear J - Cardiovasc Pharmacother. 2019;5(1):29-36. doi:10.1093/ehjcvp/pvy026

Chauveau S, Le Vavasseur O, Morel E, Dulac A, Chevalier P. Flecainide is a safe and effective treatment for pre-excited atrial fibrillation rapidly conducted to the ventricle in pregnant women: a case series. de Potter T, Sommer P, Iliodromitis K, Camm CF, Green P, eds. Eur Hear J - Case Reports. 2019;3(2). doi:10.1093/ehjcr/ytz066

Linde C, Bongiorni MG, Birgersdotter-Green U, et al. Sex differences in cardiac arrhythmia: A consensus document of the european heart rhythm association, endorsed by the heart rhythm society and Asia pacific heart rhythm society. Europace. 2018;20(10):1565-1565ao. doi:10.1093/europace/euy067

Quesada Dorador A, Prieto Martin A, Quesada B, et al. 185Effect of gender on patient selection for cardiac resynchronisation therapy. EP Eur. 2017;19(suppl_3):iii19-iii19. doi:10.1093/ehjci/eux137.004

Camm A, Amarenco P, Haas S, et al. P300Impact of gender: rivaroxaban for patients with atrial fibrillation in the XANTUS real-world prospective study. EP Eur. 2017;19(suppl_3):iii46-iii47. doi:10.1093/ehjci/eux141.028

Gillis AM. Atrial Fibrillation and Ventricular Arrhythmias. Circulation. 2017;135(6):593-608. doi:10.1161/CIRCULATIONAHA.116.025312

Ko D, Rahman F, Schnabel RB, Yin X, Benjamin EJ, Christophersen IE. Atrial fibrillation in women: Epidemiology, pathophysiology, presentation, and prognosis. Nat Rev Cardiol. 2016;13(6):321-332. doi:10.1038/nrcardio.2016.45

Piccini JP, Simon DJN, Steinberg BA, et al. Differences in clinical and functional outcomes of atrial fibrillation in women and men: Two-year results from the ORBIT-AF Registry. JAMA Cardiol. 2016;1(3):282-291. doi:10.1001/jamacardio.2016.0529

Politi C, Ciarambino T, Riva L, et al. Sex-gender and atrial fibrillation treatment in the AntiThrombotic Agents in Atrial Fibrillation (ATA-AF) study. Ital J Med. 2016;10(3):207-212. doi:10.4081/itjm.2016.649

Emdin CA, Wong CX, Hsiao AJ, et al. Atrial fibrillation as risk factor for cardiovascular disease and death in women compared with men: Systematic review and meta-analysis of cohort studies. BMJ. 2016;352. doi:10.1136/bmj.h7013

Xiong Q, Proietti M, Senoo K, Lip GYH. Asymptomatic versus symptomatic atrial fibrillation: A systematic review of age/gender differences and cardiovascular outcomes. Int J Cardiol. 2015;191:172-177. doi:10.1016/j.ijcard.2015.05.011

Lip GYH, Laroche C, Boriani G, et al. Sex-related differences in presentation, treatment, and outcome of patients with atrial fibrillation in Europe: A report from the Euro Observational Research Programme Pilot survey on Atrial Fibrillation. Europace. 2014;17(1):24-31. doi:10.1093/europace/euu155

Pancholy SB, Sharma PS, Pancholy DS, Patel TM, Callans DJ, Marchlinski FE. Meta-analysis of gender differences in residual stroke risk and major bleeding in patients with nonvalvular atrial fibrillation treated with oral anticoagulants. Am J Cardiol. 2014;113(3):485-490. doi:10.1016/j.amjcard.2013.10.035

Dagres N, Nieuwlaat R, Vardas PE, et al. Gender-Related Differences in Presentation, Treatment, and Outcome of Patients With Atrial Fibrillation in Europe. A Report From the Euro Heart Survey on Atrial Fibrillation. J Am Coll Cardiol. 2007;49(5):572-577. doi:10.1016/j.jacc.2006.10.047

Humphries KH, Kerr CR, Connolly SJ, et al. New-Onset Atrial Fibrillation. Circulation. 2001;103(19):2365-2370. doi:10.1161/01.CIR.103.19.2365

Cardiomiopatie

Cannata A, Manca P, Nuzzi V, et al. Sex-Specific Prognostic Implications in Dilated Cardiomyopathy After Left Ventricular Reverse Remodeling. J Clin Med. 2020;9(8):2426. doi:10.3390/jcm9082426

Infarto miocardico

Manfrini O, Yoon J, van der Schaar M, Kedev S, Vavlukis M, Stankovic G, Scarpone M, Miličić D, Vasiljevic Z, Badimon L, Cenko E, Bugiardini R. Sex Differences in Modifiable Risk Factors and Severity of Coronary Artery Disease. J Am Heart Assoc. 2020 Oct 20;9(19):e017235. doi:10.1161/JAHA.120.01723

Asleh R, Manemann SM, Weston SA, et al. Sex Differences in Outcomes After Myocardial Infarction in the Community. Am J Med. 2021;134(1):114-121. doi:10.1016/j.amjmed.2020.05.040

Wong ND, Cordola Hsu AR, Rozanski A, et al. Sex Differences in Coronary Artery Calcium and Mortality From Coronary Heart Disease, Cardiovascular Disease, and All Causes in Adults With Diabetes: The Coronary Calcium Consortium. Diabetes Care. 2020;43(10):2597-2606. doi:10.2337/dc20-0166

O’Donoghue ML, Sarma AA. Understanding the Sex Paradox After Percutaneous Coronary Intervention. J Am Coll Cardiol. 2020;75(14):1641-1643. doi:10.1016/j.jacc.2020.02.048

Haider A, Bengs S, Luu J, et al. Sex and gender in cardiovascular medicine: presentation and outcomes of acute coronary syndrome. Eur Heart J. 2020;41(13):1328-1336. doi:10.1093/eurheartj/ehz898

Lüscher TF. Sex and gender and cardiovascular medicine: impact in diabetes, acute coronary syndromes, and heart failure. Eur Heart J. 2020;41(13):1311-1314. doi:10.1093/eurheartj/ehaa217

Kosmidou I, Leon MB, Zhang Y, et al. Long-Term Outcomes in Women and Men Following Percutaneous Coronary Intervention. J Am Coll Cardiol. 2020;75(14):1631-1640. doi:10.1016/j.jacc.2020.01.056

Reynolds HR, Shaw LJ, Min JK, et al. Association of Sex With Severity of Coronary Artery Disease, Ischemia, and Symptom Burden in Patients With Moderate or Severe Ischemia. JAMA Cardiol. 2020;5(7):773. doi:10.1001/jamacardio.2020.0822

Bugiardini R, Cenko E. Sex differences in myocardial infarction deaths. Lancet. 2020;396(10244):72-73. doi:10.1016/S0140-6736(20)31049-7

Jackson AM, Zhang R, Findlay I, et al. Healthcare disparities for women hospitalized with myocardial infarction and angina. Eur Hear J - Qual Care Clin Outcomes. 2020;6(2):156-165. doi:10.1093/ehjqcco/qcz040

Mehta PK, Bess C, Elias-Smale S, et al. Gender in cardiovascular medicine: chest pain and coronary artery disease. Eur Heart J. Published online 12 November 2019. doi:10.1093/eurheartj/ehz784

Pacheco C, Wei J, Minissian M, et al. Cardiovascular and pregnancy outcomes in women with coronary microvascular dysfunction: a case series. Grapsa J, Abdelhamid M, Hasan H, et al., eds. Eur Hear J - Case Reports. 2019;3(2). doi:10.1093/ehjcr/ytz071

Romiti GF, Cangemi R, Toriello F, et al. Sex-Specific Cut-Offs for High-Sensitivity Cardiac Troponin: Is Less More? Cardiovasc Ther. 2019;2019:1-12. doi:10.1155/2019/9546931

Stehli J, Martin C, Brennan A, Dinh DT, Lefkovits J, Zaman S. Sex Differences Persist in Time to Presentation, Revascularization, and Mortality in Myocardial Infarction Treated With Percutaneous Coronary Intervention. J Am Heart Assoc. 2019;8(10). doi:10.1161/JAHA.119.012161

Cenko E, van der Schaar M, Yoon J, et al. Sex-Related Differences in Heart Failure After ST-Segment Elevation Myocardial Infarction. J Am Coll Cardiol. 2019;74(19):2379-2389. doi:10.1016/j.jacc.2019.08.1047

Ferry A V., Anand A, Strachan FE, et al. Presenting Symptoms in Men and Women Diagnosed With Myocardial Infarction Using Sex‐Specific Criteria. J Am Heart Assoc. 2019;8(17). doi:10.1161/JAHA.119.012307

Briller J. The Feminine Mystique in Myocardial Infarction Associated Mortality. J Am Coll Cardiol. 2019;74(19):2390-2391. doi:10.1016/j.jacc.2019.09.013

Park S-M, Wei J, Cook-Wiens G, et al. Left ventricular concentric remodelling and functional impairment in women with ischaemia with no obstructive coronary artery disease and intermediate coronary flow reserve: a report from the WISE-CVD study. Eur Hear J - Cardiovasc Imaging. 2019;20(8):875-882. doi:10.1093/ehjci/jez044

Lee KK, Ferry A V., Anand A, et al. Sex-Specific Thresholds of High-Sensitivity Troponin in Patients With Suspected Acute Coronary Syndrome. J Am Coll Cardiol. 2019;74(16):2032-2043. doi:10.1016/j.jacc.2019.07.082

Puglisi R, Mattia G, Carè A, Marano G, Malorni W, Matarrese P. Non-genomic Effects of Estrogen on Cell Homeostasis and Remodeling With Special Focus on Cardiac Ischemia/Reperfusion Injury. Front Endocrinol (Lausanne). 2019;10. doi:10.3389/fendo.2019.00733

Wenger NK. Sauce for the Goose Versus Sauce for the Gander. Circulation. 2018;137(8):791-793. doi:10.1161/CIRCULATIONAHA.118.033168

Lichtman JH, Leifheit EC, Safdar B, et al. Sex Differences in the Presentation and Perception of Symptoms Among Young Patients With Myocardial Infarction. Circulation. 2018;137(8):781-790. doi:10.1161/CIRCULATIONAHA.117.031650

Achenbach S. Coronary calcium: ‘bad news’ for men, but even ‘worse news’ for women? Eur Heart J. 2018;39(41):3736-3738. doi:10.1093/eurheartj/ehy630

Millett ERC, Peters SAE, Woodward M. Sex differences in risk factors for myocardial infarction: cohort study of UK Biobank participants. BMJ. Published online 7 November 2018:k4247. doi:10.1136/bmj.k4247

Benjamin EJ, Blaha MJ, Chiuve SE, et al. Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association. Circulation. 2017;135(10). doi:10.1161/CIR.0000000000000485

Graham G. Acute Coronary Syndromes in Women: Recent Treatment Trends and Outcomes. Clin Med Insights Cardiol. 2016;10:CMC.S37145. doi:10.4137/CMC.S37145

Park S-M, Merz CNB. Women and Ischemic Heart Disease: Recognition, Diagnosis and Management. Korean Circ J. 2016;46(4):433. doi:10.4070/kcj.2016.46.4.433

Mehta LS, Beckie TM, DeVon HA, et al. Acute Myocardial Infarction in Women. Circulation. 2016;133(9):916-947. doi:10.1161/CIR.0000000000000351

D’Onofrio G, Safdar B, Lichtman JH, et al. Sex Differences in Reperfusion in Young Patients With ST-Segment–Elevation Myocardial Infarction. Circulation. 2015;131(15):1324-1332. doi:10.1161/CIRCULATIONAHA.114.012293

Lichtman JH, Leifheit-Limson EC, Watanabe E, et al. Symptom Recognition and Healthcare Experiences of Young Women With Acute Myocardial Infarction. Circ Cardiovasc Qual Outcomes. 2015;8(2_suppl_1):S31-S38. doi:10.1161/CIRCOUTCOMES.114.001612

Xu X, Bao H, Strait K, et al. Sex Differences in Perceived Stress and Early Recovery in Young and Middle-Aged Patients With Acute Myocardial Infarction. Circulation. 2015;131(7):614-623. doi:10.1161/CIRCULATIONAHA.114.012826

Leifheit-Limson EC, D’Onofrio G, Daneshvar M, et al. Sex Differences in Cardiac Risk Factors, Perceived Risk, and Health Care Provider Discussion of Risk and Risk Modification Among Young Patients With Acute Myocardial Infarction. J Am Coll Cardiol. 2015;66(18):1949-1957. doi:10.1016/j.jacc.2015.08.859

Bucholz EM, Strait KM, Dreyer RP, et al. Effect of Low Perceived Social Support on Health Outcomes in Young Patients With Acute Myocardial Infarction: Results From the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) Study. J Am Heart Assoc. 2014;3(5). doi:10.1161/JAHA.114.001252

Scompenso cardiaco

McMurray JJV, Jackson AM, Lam CSP, et al. Effects of Sacubitril-Valsartan Versus Valsartan in Women Compared With Men With Heart Failure and Preserved Ejection Fraction. Circulation. 2020;141(5):338-351. doi:10.1161/CIRCULATIONAHA.119.044491

Jackson AM, Jhund PS, Solomon SD, McMurray JJV. Response by Jackson et al to Letter Regarding Article, “Effects of Sacubitril-Valsartan Versus Valsartan in Women Compared With Men With Heart Failure and Preserved Ejection Fraction: Insights From PARAGON-HF”. Circulation. 2020;142(1). doi:10.1161/CIRCULATIONAHA.120.047275

Stienen S, Ferreira JP, Kobayashi M, et al. Sex differences in circulating proteins in heart failure with preserved ejection fraction. Biol Sex Differ. 2020;11(1):47. doi:10.1186/s13293-020-00322-7

De Bellis A, De Angelis G, Fabris E, Cannatà A, Merlo M, Sinagra G. Gender-related differences in heart failure: beyond the “one-size-fits-all” paradigm. Heart Fail Rev. 2020;25(2):245-255. doi:10.1007/s10741-019-09824-y

Motiejūnaitė J, Akiyama E, Cohen-Solal A, et al. The association of long-term outcome and biological sex in patients with acute heart failure from different geographic regions. Eur Heart J. 2020;41(13):1357-1364. doi:10.1093/eurheartj/ehaa071

Breathett K, Yee E, Pool N, et al. Association of Gender and Race With Allocation of Advanced Heart Failure Therapies. JAMA Netw Open. 2020;3(7):e2011044. doi:10.1001/jamanetworkopen.2020.11044

Haukilahti MAE, Kenttä T V., Tikkanen JT, et al. Electrocardiographic Risk Markers for Heart Failure in Women Versus Men. Am J Cardiol. 2020;130:70-77. doi:10.1016/j.amjcard.2020.06.018

Bots SH, Groepenhoff F, Eikendal ALM, et al. Adverse Drug Reactions to Guideline-Recommended Heart Failure Drugs in Women. JACC Hear Fail. 2019;7(3):258-266. doi:10.1016/j.jchf.2019.01.009

Santema BT, Ouwerkerk W, Tromp J, et al. Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study. Lancet. 2019;394(10205):1254-1263. doi:10.1016/S0140-6736(19)31792-1

Dewan P, Rørth R, Jhund PS, et al. Differential Impact of Heart Failure With Reduced Ejection Fraction on Men and Women. J Am Coll Cardiol. 2019;73(1):29-40. doi:10.1016/j.jacc.2018.09.081

Merrill M, Sweitzer NK, Lindenfeld J, Kao DP. Sex Differences in Outcomes and Responses to Spironolactone in Heart Failure With Preserved Ejection Fraction. JACC Hear Fail. 2019;7(3):228-238. doi:10.1016/j.jchf.2019.01.003

Walsh MN, Jessup M, Lindenfeld J. Women With Heart Failure. J Am Coll Cardiol. 2019;73(1):41-43. doi:10.1016/j.jacc.2018.10.041

Bouthoorn S, Gohar A, Valstar G, et al. Prevalence of left ventricular systolic dysfunction and heart failure with reduced ejection fraction in men and women with type 2 diabetes mellitus: a systematic review and meta-analysis. Cardiovasc Diabetol. 2018;17(1):58. doi:10.1186/s12933-018-0690-3

Bouthoorn S, Valstar GB, Gohar A, et al. The prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in men and women with type 2 diabetes: A systematic review and meta-analysis. Diabetes Vasc Dis Res. 2018;15(6):477-493. doi:10.1177/1479164118787415

Eikendal ALM, Gohar A, Rutten FH, et al. Sex-Specific Relations of Cardiovascular Risk Factors With Left Ventricular Diastolic Dysfunction/Heart Failure With Preserved Ejection Fraction Are Underreported: A Call for Action. J Card Fail. 2018;24(6):412-414. doi:10.1016/j.cardfail.2018.03.001

Hassanein M, Abdelhamid M, Ibrahim B, et al. Gender differences in Egyptian patients hospitalized with heart failure: insights from the European Society of Cardiology Heart Failure Long-Term Registry. ESC Hear Fail. 2018;5(6):1159-1164. doi:10.1002/ehf2.12347

Bozkurt B, Khalaf S. Heart Failure in Women. Methodist Debakey Cardiovasc J. 2017;13(4):216-223. doi:10.14797/mdcj-13-4-216

AlBadri A, Lai K, Wei J, et al. Inflammatory biomarkers as predictors of heart failure in women without obstructive coronary artery disease: A report from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE). Bugiardini R, ed. PLoS One. 2017;12(5):e0177684. doi:10.1371/journal.pone.0177684

Toma M, Mak GJ, Chen V, et al. Differentiating heart failure phenotypes using sex-specific transcriptomic and proteomic biomarker panels. ESC Hear Fail. 2017;4(3):301-311. doi:10.1002/ehf2.12136

Sharma K, Al Rifai M, Ahmed HM, et al. Usefulness of Coronary Artery Calcium to Predict Heart Failure With Preserved Ejection Fraction in Men Versus Women (from the Multi-Ethnic Study of Atherosclerosis). Am J Cardiol. 2017;120(10):1847-1853. doi:10.1016/j.amjcard.2017.07.089

Biagi P, Verdiani V, Panigada G, Vannucchi V, Masotti L, Fortini A. Sex Differences in Characteristics and Management of Patients with Acute Heart Failure. Cardiol Cardiovasc Res. 2017;1(3):84-90. doi:10.11648/j.ccr.20170103.13

Bakir M, Nelson MD, Jones E, et al. Heart failure hospitalization in women with signs and symptoms of ischemia: A report from the women’s ischemia syndrome evaluation study. Int J Cardiol. 2016;223:936-939. doi:10.1016/j.ijcard.2016.07.301

Linde C, Stahlberg M, Benson L, et al. Gender, underutilization of cardiac resynchronization therapy, and prognostic impact of QRS prolongation and left bundle branch block in heart failure. Europace. 2015;17(3):424-431. doi:10.1093/europace/euu205

Scantlebury DC, Borlaug BA. Why are women more likely than men to develop heart failure with preserved ejection fraction? Curr Opin Cardiol. 2011;26(6):562-568. doi:10.1097/HCO.0b013e32834b7faf

Yancy CW, Fonarow GC, Albert NM, et al. Influence of patient age and sex on delivery of guideline-recommended heart failure care in the outpatient cardiology practice setting: Findings from IMPROVE HF. Am Heart J. 2009;157(4):754-762.e2. doi:10.1016/j.ahj.2008.12.016

Lenzen MJ, Rosengren A, op Reimer WJMS, et al. Management of patients with heart failure in clinical practice: differences between men and women. Heart. 2008;94(3):e10-e10. doi:10.1136/hrt.2006.099523

RUSSO AM, POOLE JE, MARK DB, et al. Primary Prevention with Defibrillator Therapy in Women: Results from the Sudden Cardiac Death in Heart Failure Trial. J Cardiovasc Electrophysiol. 2008;19(7):720-724. doi:10.1111/j.1540-8167.2008.01129.x

O’Meara E, Clayton T, McEntegart MB, et al. Sex Differences in Clinical Characteristics and Prognosis in a Broad Spectrum of Patients With Heart Failure. Circulation. 2007;115(24):3111-3120. doi:10.1161/CIRCULATIONAHA.106.673442

Gustafsson F, Kragelund CB, Torp-Pedersen C, et al. Effect of obesity and being overweight on long-term mortality in congestive heart failure: influence of left ventricular systolic function. Eur Heart J. 2005;26(1):58-64. doi:10.1093/eurheartj/ehi022

Rathore SS, Foody JM, Wang Y, et al. Sex, quality of care, and outcomes of elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project. Am Heart J. 2005;149(1):121-128. doi:10.1016/j.ahj.2004.06.008

Majahalme SK, Baruch L, Aknay N, et al. Comparison of treatment benefit and outcome in women versus men with chronic heart failure (from the Valsartan Heart Failure Trial). Am J Cardiol. 2005;95(4):529-532. doi:10.1016/j.amjcard.2004.10.026

Opasich C, De Feo S, Ambrosio GA, et al. The ‘real’ woman with heart failure. Impact of sex on current in-hospital management of heart failure by cardiologists and internists. Eur J Heart Fail. 2004;6(6):769-779. doi:10.1016/j.ejheart.2003.11.021

Ghali JK, Krause-Steinrauf HJ, Adams KF, et al. Gender differences in advanced heart failure: insights from the BEST study. J Am Coll Cardiol. 2003;42(12):2128-2134. doi:10.1016/j.jacc.2003.05.012

Rathore SS, Wang Y, Krumholz HM. Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure. N Engl J Med. 2002;347(18):1403-1411. doi:10.1056/NEJMoa021266

Ghali JK, Piña IL, Gottlieb SS, Deedwania PC, Wikstrand JC. Metoprolol CR/XL in Female Patients With Heart Failure. Circulation. 2002;105(13):1585-1591. doi:10.1161/01.CIR.0000012546.20194.33

Simon T, Mary-Krause M, Funck-Brentano C, Jaillon P. Sex Differences in the Prognosis of Congestive Heart Failure. Circulation. 2001;103(3):375-380. doi:10.1161/01.CIR.103.3.375

Shah MR, Granger CB, Bart BA, et al. Sex-related differences in the use and adverse effects of angiotensin-converting enzyme inhibitors in heart failure: the study of patients intolerant of converting enzyme inhibitors registry. Am J Med. 2000;109(6):489-492. doi:10.1016/S0002-9343(00)00529-5

Trombosi ed embolia

Tagalakis V. Sex may matter when it comes to the presenting location of deep vein thrombosis. Thromb Res. 2019;173:164-165. doi:10.1016/j.thromres.2018.12.001

Kaltenmeier CT, Erben Y, Indes J, et al. Systematic review of May-Thurner syndrome with emphasis on gender differences. J Vasc Surg Venous Lymphat Disord. 2018;6(3):399-407.e4. doi:10.1016/j.jvsv.2017.11.006

Bleker SM, Coppens M, Middeldorp S. Sex, thrombosis and inherited thrombophilia. Blood Rev. 2014;28(3):123-133. doi:10.1016/j.blre.2014.03.005

Blanco-Molina A, Trujillo-Santos J, Tirado R, et al. Venous thromboembolism in women using hormonal contraceptives. Findings from the RIETE Registry. Thromb Haemost. 2009;101(3):478-482. Thromb Haemost.

Altro

Walli-Attaei M, Joseph P, Rosengren A, et al. Variations between women and men in risk factors, treatments, cardiovascular disease incidence, and death in 27 high-income, middle-income, and low-income countries (PURE): a prospective cohort study. Lancet. 2020;396(10244):97-109. doi:10.1016/S0140-6736(20)30543-2

Mosca L, Navar AM, Wenger NK. Reducing Cardiovascular Disease Risk in Women Beyond Statin Therapy: New Insights 2020. J Women’s Heal. 2020;29(8):1091-1100. doi:10.1089/jwh.2019.8189

Kurth T, Rist PM, Ridker PM, Kotler G, Bubes V, Buring JE. Association of Migraine With Aura and Other Risk Factors With Incident Cardiovascular Disease in Women. JAMA. 2020;323(22):2281. doi:10.1001/jama.2020.7172

Okoth K, Chandan JS, Marshall T, et al. Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review. BMJ. Published online 7 October 2020:m3502. doi:10.1136/bmj.m3502

Kuehn BM. Getting to the Heart of Sex Differences. Circulation. 2020;141(14):1198-1199. doi:10.1161/CIRCULATIONAHA.120.046557

Mueller KAL, Hanna DB, Ehinger E, et al. Loss of CXCR4 on non-classical monocytes in participants of the Women’s Interagency HIV Study (WIHS) with subclinical atherosclerosis. Cardiovasc Res. 2019;115(6):1029-1040. doi:10.1093/cvr/cvy292

Gerdts E, Regitz-Zagrosek V. Sex differences in cardiometabolic disorders. Nat Med. 2019;25(11):1657-1666. doi:10.1038/s41591-019-0643-8

AlSiraj Y, Chen X, Thatcher SE, et al. XX sex chromosome complement promotes atherosclerosis in mice. Nat Commun. 2019;10(1):2631. doi:10.1038/s41467-019-10462-z

Shoemaker R, Tannock LR, Su W, et al. Adipocyte deficiency of ACE2 increases systolic blood pressures of obese female C57BL/6 mice. Biol Sex Differ. 2019;10(1):45. doi:10.1186/s13293-019-0260-8

Fiechter M, Roggo A, Burger IA, et al. Association between resting amygdalar activity and abnormal cardiac function in women and men: a retrospective cohort study. Eur Hear J - Cardiovasc Imaging. 2019;20(6):625-632. doi:10.1093/ehjci/jez047

Blom MT, Oving I, Berdowski J, van Valkengoed IGM, Bardai A, Tan HL. Women have lower chances than men to be resuscitated and survive out-of-hospital cardiac arrest. Eur Heart J. 2019;40(47):3824-3834. doi:10.1093/eurheartj/ehz297

van Koeverden ID, de Bakker M, Haitjema S, et al. Testosterone to oestradiol ratio reflects systemic and plaque inflammation and predicts future cardiovascular events in men with severe atherosclerosis. Cardiovasc Res. 2019;115(2):453-462. doi:10.1093/cvr/cvy188

Ghadri J-R, Wittstein IS, Prasad A, et al. International Expert Consensus Document on Takotsubo Syndrome (Part II): Diagnostic Workup, Outcome, and Management. Eur Heart J. 2018;39(22):2047-2062. doi:10.1093/eurheartj/ehy077

Onose T, Sakata Y, Nochioka K, et al. Sex differences in post-traumatic stress disorder in cardiovascular patients after the Great East Japan Earthquake: a report from the CHART-2 Study. Eur Hear J - Qual Care Clin Outcomes. 2017;3(3):224-233. doi:10.1093/ehjqcco/qcx009

Tamargo J, Rosano G, Walther T, et al. Gender differences in the effects of cardiovascular drugs. Eur Hear J - Cardiovasc Pharmacother. 2017;3(3):163-182. doi:10.1093/ehjcvp/pvw042

Garcia M, Mulvagh SL, Bairey Merz CN, Buring JE, Manson JE. Cardiovascular Disease in Women. Circ Res. 2016;118(8):1273-1293. doi:10.1161/CIRCRESAHA.116.307547

Yusuf S, Rangarajan S, Teo K, et al. Cardiovascular Risk and Events in 17 Low-, Middle-, and High-Income Countries. N Engl J Med. 2014;371(9):818-827. doi:10.1056/NEJMoa1311890

Apparato Muscolo-Scheletrico

Chirurgia Protesica

Sappey-Marinier E, Swan J, Batailler C, Servien E, Lustig S. No clinical benefit from gender-specific total knee replacement implants: a systematic review. SICOT-J. 2020;6:25. doi:10.1051/sicotj/2020023

Hennessy D, Arauz P, Klemt C, An S, Kwon Y-M. Gender Influences Gait Asymmetry following Bicruciate-Retaining Total Knee Arthroplasty. J Knee Surg. 2020;33(06):582-588. doi:10.1055/s-0039-1681092

Patel AP, Gronbeck C, Chambers M, Harrington MA, Halawi MJ. Gender and Total Joint Arthroplasty: Variable Outcomes by Procedure Type. Arthroplast Today. 2020;6(3):517-520. doi:10.1016/j.artd.2020.06.012

Gallo J, Kriegova E, Kudelka M, Lostak J, Radvansky M. Gender Differences in Contribution of Smoking, Low Physical Activity, and High BMI to Increased Risk of Early Reoperation After TKA. J Arthroplasty. 2020;35(6):1545-1557. doi:10.1016/j.arth.2020.01.056

Gu A, Wei C, Bernstein SA, et al. The Impact of Gender on Postoperative Complications after Revision Total Knee Arthroplasty. J Knee Surg. 2020;33(04):387-393. doi:10.1055/s-0039-1677820

Perez B, Slover J, Edusei E, et al. Impact of gender and race on expectations and outcomes in total knee arthroplasty. World J Orthop. 2020;11(5):265-277. doi:10.5312/wjo.v11.i5.265

Schiffner E, Latz D, Thelen S, et al. Aseptic Loosening after THA and TKA - Do gender, tobacco use and BMI have an impact on implant survival time? J Orthop. 2019;16(3):269-272. doi:10.1016/j.jor.2019.03.018

Basques BA, Bell JA, Fillingham YA, Khan JM, Della Valle CJ. Gender Differences for Hip and Knee Arthroplasty: Complications and Healthcare Utilization. J Arthroplasty. 2019;34(8):1593-1597.e1. doi:10.1016/j.arth.2019.03.064

Tummala S, Schiphof D, Byrjalsen I, Dam EB. Gender Differences in Knee Joint Congruity Quantified from MRI: A Validation Study with Data from Center for Clinical and Basic Research and Osteoarthritis Initiative. Cartilage. 2018;9(1):38-45. doi:10.1177/1947603516684590

Hughes-Oliver CN, Srinivasan D, Schmitt D, Queen RM. Gender and limb differences in temporal gait parameters and gait variability in ankle osteoarthritis. Gait Posture. 2018;65:228-233. doi:10.1016/j.gaitpost.2018.07.180

Liu R, Yuan X, Yu J, et al. An updated meta-analysis of the asporin gene D-repeat in knee osteoarthritis: effects of gender and ethnicity. J Orthop Surg Res. 2017;12(1):148. doi:10.1186/s13018-017-0647-3

Robinson J, Shin JI, Dowdell JE, Moucha CS, Chen DD. Impact of Gender on 30-Day Complications After Primary Total Joint Arthroplasty. J Arthroplasty. 2017;32(8):2370-2374. doi:10.1016/j.arth.2017.03.001

Phinyomark A, Osis ST, Hettinga BA, Kobsar D, Ferber R. Gender differences in gait kinematics for patients with knee osteoarthritis. BMC Musculoskelet Disord. 2016;17(1):157. doi:10.1186/s12891-016-1013-z

Windisch C, Brodt S, Roehner E, Matziolis G. The C-reactive protein level after total knee arthroplasty is gender specific. Knee Surgery, Sport Traumatol Arthrosc. 2016;24(10):3163-3167. doi:10.1007/s00167-016-4289-5

Bawa HS, Weick JW, Dirschl DR. Gender Disparities in Osteoarthritis-Related Health Care Utilization Before Total Knee Arthroplasty. J Arthroplasty. 2016;31(10):2115-2118.e1. doi:10.1016/j.arth.2016.03.044

Lu Y, Zhou Z-Y, Liu Y-K, Chen H-L, Yang H-L, Liu F. Gender differences of venous thromboembolism risk after total hip and total knee arthroplasty: a meta-analysis. J Thromb Thrombolysis. 2016;41(4):556-562. doi:10.1007/s11239-015-1283-6

Lim JBT, Chong HC, Ling K, et al. Gender-Specific Total Knee Arthroplasty in Singaporean Women. J Orthop Surg. 2015;23(2):190-193. doi:10.1177/230949901502300215

Prieto-Alhambra D, Judge A, Javaid MK, Cooper C, Diez-Perez A, Arden NK. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis. 2014;73(9):1659-1664. doi:10.1136/annrheumdis-2013-203355

Pollard B, Dixon D, Johnston M. Does the impact of osteoarthritis vary by age, gender and social deprivation? A community study using the International Classification of Functioning, Disability and Health. Disabil Rehabil. 2014;36(17):1445-1451. doi:10.3109/09638288.2013.847123

O’Connor MI, Hooten EG. Breakout Session: Gender Disparities in Knee Osteoarthritis and TKA. Clin Orthop Relat Res. 2011;469(7):1883-1885. doi:10.1007/s11999-010-1743-4

Low Back Pain

Fehrmann E, Kotulla S, Fischer L, et al. The impact of age and gender on the ICF-based assessment of chronic low back pain. Disabil Rehabil. 2019;41(10):1190-1199. doi:10.1080/09638288.2018.1424950

Kizhakkeveettil A, Rose KA, Kadar GE, Hurwitz EL. An Exploratory Analysis of Gender as a Potential Modifier of Treatment Effect Among Patients in a Randomized Controlled Trial of Integrative Acupuncture and Spinal Manipulation for Low Back Pain. J Manipulative Physiol Ther. 2019;42(3):177-186. doi:10.1016/j.jmpt.2018.11.005

Kikuchi R, Hirano T, Watanabe K, et al. Gender differences in the prevalence of low back pain associated with sports activities in children and adolescents: a six-year annual survey of a birth cohort in Niigata City, Japan. BMC Musculoskelet Disord. 2019;20(1):327. doi:10.1186/s12891-019-2707-9

Ungureanu G, Chitu A, Iancu I, Kakucs C, Maior T, Florian IS. Gender Differences in the Self-assessment of Quality of Life and Disability After Spinal Fusion for Chronic Low Back Pain at a Neurosurgical Center in Eastern Europe. Neurospine. 2018;15(3):261-268. doi:10.14245/ns.1836076.038

Ozcan Kahraman B, Kahraman T, Kalemci O, Salik Sengul Y. Gender differences in postural control in people with nonspecific chronic low back pain. Gait Posture. 2018;64:147-151. doi:10.1016/j.gaitpost.2018.06.026

Sung PS, Zipple JT, Danial P. Gender differences in asymmetrical limb support patterns between subjects with and without recurrent low back pain. Hum Mov Sci. 2017;52:36-44. doi:10.1016/j.humov.2017.01.002

Wáng YXJ, Wáng J-Q, Káplár Z. Increased low back pain prevalence in females than in males after menopause age: evidences based on synthetic literature review. Quant Imaging Med Surg. 2016;6(2):199-206. doi:10.21037/qims.2016.04.06

Yang H, Haldeman S, Lu M-L, Baker D. Low Back Pain Prevalence and Related Workplace Psychosocial Risk Factors: A Study Using Data From the 2010 National Health Interview Survey. J Manipulative Physiol Ther. 2016;39(7):459-472. doi:10.1016/j.jmpt.2016.07.004

Pries E, Dreischarf M, Bashkuev M, Putzier M, Schmidt H. The effects of age and gender on the lumbopelvic rhythm in the sagittal plane in 309 subjects. J Biomech. 2015;48(12):3080-3087. doi:10.1016/j.jbiomech.2015.07.030

Ono R, Yamazaki S, Takegami M, et al. Gender Difference in Association Between Low Back Pain and Metabolic Syndrome. Spine (Phila Pa 1976). 2012;37(13):1130-1137. doi:10.1097/BRS.0b013e31824231b8

Osteoporosi, Osteoartrosi

Noh J-W, Park H, Kim M, Kwon YD. Gender Differences and Socioeconomic Factors Related to Osteoporosis: A Cross-Sectional Analysis of Nationally Representative Data. J Women’s Heal. 2018;27(2):196-202. doi:10.1089/jwh.2016.6244

Kim KM, Lim S, Oh TJ, et al. Longitudinal Changes in Muscle Mass and Strength, and Bone Mass in Older Adults: Gender-Specific Associations Between Muscle and Bone Losses. Journals Gerontol Ser A. 2018;73(8):1062-1069. doi:10.1093/gerona/glx188

Hammond I, Lentle B, van den Berg L, Vitols-McKay M. Gender Identity and Bone Densitometry. Can Assoc Radiol J. 2017;68(3):267-269. doi:10.1016/j.carj.2016.10.006

Ansari H, Beaton DE, Sujic R, et al. Equal treatment: no evidence of gender inequity in osteoporosis management in a coordinator-based fragility fracture screening program. Osteoporos Int. 2017;28(12):3401-3406. doi:10.1007/s00198-017-4206-x

Aurrecoechea E, Llorca Díaz J, Diez Lizuain ML, McGwin G, Calvo-Alen J. Gender-associated comorbidities in rheumatoid arthritis and their impact on outcome: data from GENIRA. Rheumatol Int. 2017;37(4):479-485. doi:10.1007/s00296-016-3628-7

Barkaoui A, Ben Kahla R, Merzouki T, Hambli R. Age and gender effects on bone mass density variation: finite elements simulation. Biomech Model Mechanobiol. 2017;16(2):521-535. doi:10.1007/s10237-016-0834-x

Brüggmann D, Mäule L-S, Klingelhöfer D, et al. World-wide architecture of osteoporosis research: density-equalizing mapping studies and gender analysis. Climacteric. 2016;19(5):463-470. doi:10.1080/13697137.2016.1200548

Prieto-Alhambra D, Judge A, Javaid MK, Cooper C, Diez-Perez A, Arden NK. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis. 2014;73(9):1659-1664. doi:10.1136/annrheumdis-2013-203355

Pietschmann P, Kerschan-Schindl K. Osteoporosis: Gender-specific aspects. Wiener Medizinische Wochenschrift. 2004;154(17-18):411-415. doi:10.1007/s10354-004-0100-1

Melton LJ. The Prevalence of Osteoporosis: Gender and Racial Comparison. Calcif Tissue Int. 2001;69(4):179-181. doi:10.1007/s00223-001-1043-9

Traumatologia

Galbraith AS, Sanz‐Nogués C, Glynn S, Coleman CM, Murphy C. Diabetes Mellitus and Gender Have a Negative Impact on the Outcome of Hip Fracture Surgery—A Pilot Study. J Orthop Res. 2020;38(4):834-842. doi:10.1002/jor.24517

Wang H, Liu H, Wu J, et al. Age, gender, and etiology differences of sports-related fractures in children and adolescents. Medicine (Baltimore). 2019;98(4):e13961. doi:10.1097/MD.0000000000013961

Vranken L, Wyers CE, Van der Velde RY, et al. Comorbidities and medication use in patients with a recent clinical fracture at the Fracture Liaison Service. Osteoporos Int. 2018;29(2):397-407. doi:10.1007/s00198-017-4290-y

Gioffrè-Florio M. Trauma in elderly patients: a study of prevalence, comorbidities and gender differences. G di Chir - J Surg. 2018;39(1):35. doi:10.11138/gchir/2018.39.1.035

Bolandparvaz S, Yadollahi M, Abbasi HR, Anvar M. Injury patterns among various age and gender groups of trauma patients in southern Iran. Medicine (Baltimore). 2017;96(41):e7812. doi:10.1097/MD.0000000000007812

Boesmueller S, Huf W, Rettl G, et al. The influence of sex and trauma impact on the rupture site of the ulnar collateral ligament of the thumb. Wang JH-C, ed. PLoS One. 2017;12(7):e0181754. doi:10.1371/journal.pone.0181754

Saletti-Cuesta L, Tutton L, Wright J. The relevance of gender in the care of hip fracture patients. Int J Orthop Trauma Nurs. 2016;22:3-12. doi:10.1016/j.ijotn.2015.10.004

Sterling RS. Gender and Race/Ethnicity Differences in Hip Fracture Incidence, Morbidity, Mortality, and Function. Clin Orthop Relat Res. 2011;469(7):1913-1918. doi:10.1007/s11999-010-1736-3

Geusens P, Dinant G. Integrating a Gender Dimension into Osteoporosis and Fracture Risk Research. Gend Med. 2007;4:S147-S161. doi:10.1016/S1550-8579(07)80055-6

Beck T., Ruff C., Shaffer R., Betsinger K, Trone D., Brodine S. Stress fracture in military recruits: gender differences in muscle and bone susceptibility factors. Bone. 2000;27(3):437-444. doi:10.1016/S8756-3282(00)00342-2

Apparato Respiratorio

Asma bronchiale

Barbagelata E, Cilloniz C, Nicolini A, Moretti AM. Sex differences in asthma and immunological response: An overview. Ital J Gender-Specific Med. 2019;5(2):68-73. doi:10.1723/3188.31665

Yang CX, Shi H, Ding I, et al. Widespread Sexual Dimorphism in the Transcriptome of Human Airway Epithelium in Response to Smoking. Sci Rep. 2019;9(1):1-14. doi:10.1038/s41598-019-54051-y

Ambhore NS, Kalidhindi RSR, Pabelick CM, Hawse JR, Prakash YS, Sathish V. Differential estrogen-receptor activation regulates extracellular matrix deposition in human airway smooth muscle remodeling via NF-κB pathway. FASEB J. 2019;33(12):13935-13950. doi:10.1096/fj.201901340R

Baldaçara RP de C, Silva I. Association between asthma and female sex hormones. Sao Paulo Med J. 2017;135(1):4-14. doi:10.1590/1516-3180.2016.011827016

Fuseini H, Newcomb DC. Mechanisms Driving Gender Differences in Asthma. Curr Allergy Asthma Rep. 2017;17(3):19. doi:10.1007/s11882-017-0686-1

Koper I, Hufnagl K, Ehmann R. Gender aspects and influence of hormones on bronchial asthma – Secondary publication and update. World Allergy Organ J. 2017;10:46. doi:10.1186/s40413-017-0177-9

Scott HA, Gibson PG, Garg ML, Upham JW, Wood LG. Sex hormones and systemic inflammation are modulators of the obese-asthma phenotype. Allergy. 2016;71(7):1037-1047. doi:10.1111/all.12891

BPCO

Yang CX, Shi H, Ding I, et al. Widespread Sexual Dimorphism in the Transcriptome of Human Airway Epithelium in Response to Smoking. Sci Rep. 2019;9(1):1-14. doi:10.1038/s41598-019-54051-y

Ambrosino I, Gallone MS, Patano F, et al. Gender differences in chronic obstructive pulmonary disease: an analysis of hospitalization indicators. Ital J Med. 2019;13(1):38-44. doi:10.4081/itjm.2019.1099

Giannico OV, Ambrosino I, Patano F, Germinario C, Quarto M, Moretti AM. Educational level, marital status and sex as social gender discharge determinants in chronic obstructive pulmonary disease exacerbations: a time-to-event analysis. Monaldi Arch Chest Dis. 2019;89(2). doi:10.4081/monaldi.2019.1017

Barbagelata E, Nicolini A, Ambrosino I, Politi C. Gender differences and chronic obstructive pulmonary disease: an update on the literature. Ital J Med. 2018;12(3):171-179. doi:10.4081/itjm.2018.987

Barnes PJ. Sex Differences in Chronic Obstructive Pulmonary Disease Mechanisms. Am J Respir Crit Care Med. 2016;193(8):813-814. doi:10.1164/rccm.201512-2379ED

Tam A, Bates JHT, Churg A, Wright JL, Man SFP, Sin DD. Sex-Related Differences in Pulmonary Function following 6 Months of Cigarette Exposure: Implications for Sexual Dimorphism in Mild COPD. Fehrenbach H, ed. PLoS One. 2016;11(10):e0164835. doi:10.1371/journal.pone.0164835

Henoch I, Strang S, Löfdahl C-G, Ekberg-Jansson A. Management of COPD, equal treatment across age, gender, and social situation? A register study. Int J Chron Obstruct Pulmon Dis. 2016;Volume 11:2681-2690. doi:10.2147/COPD.S115238

Luoto JA, Elmståhl S, Wollmer P, Pihlsgård M. Incidence of airflow limitation in subjects 65–100 years of age. Eur Respir J. 2016;47(2):461-472. doi:10.1183/13993003.00635-2015

Kokturk N, Bakir H, Sari G, Cakir M. Do females behave differently in COPD exacerbation? Int J Chron Obstruct Pulmon Dis. Published online April 2015:823. doi:10.2147/COPD.S78952

Assad N, Balmes J, Mehta S, Cheema U, Sood A. Chronic Obstructive Pulmonary Disease Secondary to Household Air Pollution. Semin Respir Crit Care Med. 2015;36(03):408-421. doi:10.1055/s-0035-1554846

Mannino D, Aryal S, Diaz E. Influence of sex on chronic obstructive pulmonary disease risk and treatment outcomes. Int J Chron Obstruct Pulmon Dis. Published online October 2014:1145. doi:10.2147/COPD.S54476

Robles PG, Brooks D, Goldstein R, Salbach N, Mathur S. Gender-Associated Differences in Pulmonary Rehabilitation Outcomes in People With Chronic Obstructive Pulmonary Disease. J Cardiopulm Rehabil Prev. 2014;34(2):87-97. doi:10.1097/HCR.0000000000000018

Roche N, Deslée G, Caillaud D, et al. Impact of gender on COPD expression in a real-life cohort. Respir Res. 2014;15(1):20. doi:10.1186/1465-9921-15-20

Gonzalez A V., Suissa S, Ernst P. Gender differences in survival following hospitalisation for COPD. Thorax. 2011;66(1):38-42. doi:10.1136/thx.2010.141978

Celli B, Vestbo J, Jenkins CR, et al. Sex Differences in Mortality and Clinical Expressions of Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2011;183(3):317-322. doi:10.1164/rccm.201004-0665OC

Sorheim I-C, Johannessen A, Gulsvik A, Bakke PS, Silverman EK, DeMeo DL. Gender differences in COPD: are women more susceptible to smoking effects than men? Thorax. 2010;65(6):480-485. doi:10.1136/thx.2009.122002

Chapman K R Diagnosis and treatment considerations for women with COPD Int J Clin Prat 2009,63(3): 486.493

Camp PG, O’Donnell DE, Postma DS. Chronic Obstructive Pulmonary Disease in Men and Women: Myths and Reality. Proc Am Thorac Soc. 2009;6(6):535-538. doi:10.1513/pats.200904-018DS

Cote CG, Chapman KR. Diagnosis and treatment considerations for women with COPD. Int J Clin Pract. 2009;63(3):486-493. doi:10.1111/j.1742-1241.2008.01987.x

Bischoff EWMA, Schermer TRJ, Brown P et al. Women with Low Socioeconomic Status Deserve Specific Attention in Preventing and Managing COPD. Wonca World Conference, Singapore, 2007

Han MK, Postma D, Mannino DM, et al. Gender and Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2007;176(12):1179-1184. doi:10.1164/rccm.200704-553CC

Laviolette L, Lacasse Y, Doucet M, et al. Chronic Obstructive Pulmonary Disease in Women. Can Respir J. 2007;14(2):93-98. doi:10.1155/2007/463435

Mannino DM, Buist AS. Global burden of COPD: risk factors, prevalence, and future trends. Lancet. 2007;370(9589):765-773. doi:10.1016/S0140-6736(07)61380-4

Dransfield MT, Washko GR, Foreman MG, Estepar RSJ, Reilly J, Bailey WC. Gender Differences in the Severity of CT Emphysema in COPD. Chest. 2007;132(2):464-470. doi:10.1378/chest.07-0863

Gan WQ, Man SP, Postma DS, Camp P, Sin DD. Female smokers beyond the perimenopausal period are at increased risk of chronic obstructive pulmonary disease: a systematic review and meta-analysis. Respir Res. 2006;7(1):52. doi:10.1186/1465-9921-7-52

Watson L, et al. Predictors of lung function  and its decline in mild to moderate COPD in association with gender: results from the Euroscop study  Respir Med 2006; 100: 746–53

Watson L, et al. Predictors of lung function  and its decline in mild to moderate COPD in association with gender: results from the Euroscop study  Respir Med 2006; 100: 746–53

De Torres JP, et al.  Gender and COPD in patients attending a pulmonary clinic Chest 2005; 128: 2012–6

Watson L, et al. Gender differences in the management and experience of chronic obstructive pulmonary disease  Respir Med 2004; 98: 1207–13

Chapman KR, Tashkin DP, Pye DJ. Gender bias in the diagnosis of COPD. Chest 2001;119.1691-1695Cote C G,

Engstrom CP, Persson LO, Larson S, Sullivan M. Health related quality of life in COPD: Why both disease-specific and generic measures should be used. Eur Respir J 2001; 18:69–76.

 

Silverman EK, Weiss ST, et al. Gender-related differences in severe,early-onset chronic obstructive pulmonary disease. Am J Respir Crit Care Med., 2000; 162: 2152-2158

Soriano JB. Recent trends in physician diagnosed COPD in women and men in the UK. Thorax. 2000;55(9):789-794. doi:10.1136/thorax.55.9.789

Embolia

Masotti L, Panigada G, Landini G, et al. Simplified PESI score and sex difference in prognosis of acute pulmonary embolism: a brief report from a real life study. J Thromb Thrombolysis. 2016;41(4):606-612. doi:10.1007/s11239-015-1260-0

Dentali F, Ageno W, Pomero F, et al. Time trends and case fatality rate of in-hospital treated pulmonary embolism during 11 years of observation in Northwestern Italy. Thrombosis and Haemostasis. 2016 Jan;115(2):399-405. DOI: 10.1160/th15-02-0172.

Agarwal S, Clark D, Sud K, Jaber WA, Cho L, Menon V. Gender Disparities in Outcomes and Resource Utilization for Acute Pulmonary Embolism Hospitalizations in the United States. Am J Cardiol. 2015;116(8):1270-1276. doi:10.1016/j.amjcard.2015.07.048

 

Enfisema

Martinez FJ, Curtis JL, Sciurba F, et al. Sex Differences in Severe Pulmonary Emphysema. Am J Respir Crit Care Med. 2007;176(3):243-252. doi:10.1164/rccm.200606-828OC

Ipertensione polmonare

Umar S, Cunningham CM, Itoh Y, et al. The Y Chromosome Plays a Protective Role in Experimental Hypoxic Pulmonary Hypertension. Am J Respir Crit Care Med. 2018;197(7):952-955. doi:10.1164/rccm.201707-1345LE

Polmonite

Cillóniz C, Dominedò C, Torres A. Multidrug Resistant Gram-Negative Bacteria in Community-Acquired Pneumonia. Crit Care. 2019;23(1):79. doi:10.1186/s13054-019-2371-3

Raeven VM, Spoorenberg SMC, Boersma WG, et al. Atypical aetiology in patients hospitalised with community-acquired pneumonia is associated with age, gender and season; a data-analysis on four Dutch cohorts. BMC Infect Dis. 2016;16(1):299. doi:10.1186/s12879-016-1641-9

Altro

Kawano-Dourado L, Glassberg MK, Molina-Molina M, Strek ME, Wijsenbeek M, Johannson KA. Gender equity in interstitial lung disease. Lancet Respir Med. 2020;8(9):842-843. doi:10.1016/S2213-2600(20)30310-6

Dolore

Shaefer JR, Khawaja SN, Bavia PF. Sex, Gender, and Orofacial Pain. Dent Clin North Am. 2018;62(4):665-682. doi:10.1016/j.cden.2018.06.001

Samulowitz A, Gremyr I, Eriksson E, Hensing G. “Brave Men” and “Emotional Women”: A Theory-Guided Literature Review on Gender Bias in Health Care and Gendered Norms towards Patients with Chronic Pain. Pain Res Manag. 2018;2018:1-14. doi:10.1155/2018/6358624

Vacca V, Marinelli S, Pieroni L, Urbani A, Luvisetto S, Pavone F. 17beta-estradiol counteracts neuropathic pain: a behavioural, immunohistochemical and proteomic investigation on sex-related differences in mice. Sci Rep. 2016;6(1):18980. doi:10.1038/srep18980

Pieretti S, Di Giannuario A, Di Giovannandrea R, et al. Gender differences in pain and its relief. Ann Ist Super Sanita. 2016;52(2):184-189. doi:10.4415/ANN_16_02_09

Traub RJ, Ji Y. Sex differences and hormonal modulation of deep tissue pain. Front Neuroendocrinol. 2013;34(4):350-366. doi:10.1016/j.yfrne.2013.07.002

Mogil JS. Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon. Nat Rev Neurosci. 2012;13(12):859-866. doi:10.1038/nrn3360

Mogil JS, Bailey AL. Sex and gender differences in pain and analgesia. In: Prog Brain Res. ; 2010:140-157. doi:10.1016/B978-0-444-53630-3.00009-9

Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL. Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings. J Pain. 2009;10(5):447-485. doi:10.1016/j.jpain.2008.12.001

Endocrinologia

Diabete

Murro I, Di Noia C., Penza A, De Pergola G. Diabete mellito di tipo 2 e medicina di genere.Il Diabete Online, Organo ufficiale della Società Italiana di Diabetologia, Rassegna, Vol. 32 N. 4 2020. doi:10.30682/ildia2004

de Ritter R, de Jong M, Vos RC, et al. Sex differences in the risk of vascular disease associated with diabetes. Biol Sex Differ. 2020;11(1):1. doi:10.1186/s13293-019-0277-z

Crump C, Sundquist J, Sundquist K. Preterm birth and risk of type 1 and type 2 diabetes: a national cohort study. Diabetologia. 2020;63(3):508-518. doi:10.1007/s00125-019-05044-z

Barron E, Bakhai C, Kar P, et al. Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study. Lancet Diabetes Endocrinol. 2020;8(10):813-822. doi:10.1016/S2213-8587(20)30272-2

Sattar N. Type 2 diabetes-related sex differences in cardiovascular risk: reasons, ramifications, and clinical realities. Eur Heart J. 2020;41(13):1354-1356. doi:10.1093/eurheartj/ehz914

Malmborg M, Schmiegelow MDS, Nørgaard CH, et al. Does type 2 diabetes confer higher relative rates of cardiovascular events in women compared with men? Eur Heart J. 2020;41(13):1346-1353. doi:10.1093/eurheartj/ehz913

Raparelli V, Proietti M, Romiti GF, Lenzi A, Basili S. The Sex-Specific Detrimental Effect of Diabetes and Gender-Related Factors on Pre-admission Medication Adherence Among Patients Hospitalized for Ischemic Heart Disease: Insights From EVA Study. Front Endocrinol (Lausanne). 2019;10. doi:10.3389/fendo.2019.00107

Wang Y, O’Neil A, Jiao Y, et al. Sex differences in the association between diabetes and risk of cardiovascular disease, cancer, and all-cause and cause-specific mortality: a systematic review and meta-analysis of 5,162,654 participants. BMC Med. 2019;17(1):136. doi:10.1186/s12916-019-1355-0

Al-Salameh A, Chanson P, Bucher S, Ringa V, Becquemont L. Cardiovascular Disease in Type 2 Diabetes: A Review of Sex-Related Differences in Predisposition and Prevention. Mayo Clin Proc. 2019;94(2):287-308. doi:10.1016/j.mayocp.2018.08.007

Manicardi V, Russo G, Rossi MC. Donne, diabete e rischio cardiovascolare. JAMD. 2019;21(4).

Huebschmann AG, Huxley RR, Kohrt WM, Zeitler P, Regensteiner JG, Reusch JEB. Sex differences in the burden of type 2 diabetes and cardiovascular risk across the life course. Diabetologia. 2019;62(10):1761-1772. doi:10.1007/s00125-019-4939-5

Peters SAE, Woodward M. Sex Differences in the Burden and Complications of Diabetes. Curr Diab Rep. 2018;18(6):33. doi:10.1007/s11892-018-1005-5

Mauvais-Jarvis F. Gender differences in glucose homeostasis and diabetes. Physiol Behav. 2018;187:20-23. doi:10.1016/j.physbeh.2017.08.016

Harreiter J, Kautzky-Willer A. Sex and Gender Differences in Prevention of Type 2 Diabetes. Front Endocrinol (Lausanne). 2018;9. doi:10.3389/fendo.2018.00220

Escolar-Pujolar A, Córdoba Doña JA, Goicolea Julían I, et al. The effect of marital status on social and gender inequalities in diabetes mortality in Andalusia. Endocrinol Diabetes y Nutr. 2018;65(1):21-29. doi:10.1016/j.endinu.2017.10.006

Kautzky-Willer A, Harreiter J. Sex and gender differences in therapy of type 2 diabetes. Diabetes Res Clin Pract. 2017;131:230-241. doi:10.1016/j.diabres.2017.07.012

Kautzky-Willer A, Harreiter J, Pacini G. Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus. Endocr Rev. 2016;37(3):278-316. doi:10.1210/er.2015-1137

Russo GT, Giandalia A, Romeo EL, et al. Fracture Risk in Type 2 Diabetes: Current Perspectives and Gender Differences. Int J Endocrinol. 2016;2016:1-11. doi:10.1155/2016/1615735

Oikonomou E, Tsigkou V, Lazaros G, et al. The Interaction Between Gender and Diabetes Mellitus in the Coronary Heart Disease Risk. Curr Pharm Des. 2016;22(25):3802-3816. doi:10.2174/1381612822666160606202111

Manicardi V, Russo G, Napoli A, et al. Gender-Disparities in Adults with Type 1 Diabetes: More Than a Quality of Care Issue. A Cross-Sectional Observational Study from the AMD Annals Initiative. Manzoli L, ed. PLoS One. 2016;11(10):e0162960. doi:10.1371/journal.pone.0162960

Manicardi V, Rossi MC, Romeo EL, et al. Gender differences in type 2 diabetes (Italy). Ital J Gender-Specific Med. 2016;2(2):60-68. doi:http://dx.doi.org/10.1723/2446.25648

Russo G, Pintaudi B, Giorda C, et al. Age- and Gender-Related Differences in LDL-Cholesterol Management in Outpatients with Type 2 Diabetes Mellitus. Int J Endocrinol. 2015;2015:1-8. doi:10.1155/2015/957105

Glechner A, Harreiter J, Gartlehner G, et al. Sex-specific differences in diabetes prevention: a systematic review and meta-analysis. Diabetologia. 2015;58(2):242-254. doi:10.1007/s00125-014-3439-x

Arnetz L, Rajamand Ekberg N, Alvarsson M. Sex differences in type 2 diabetes: focus on disease course and outcomes. Diabetes, Metab Syndr Obes Targets Ther. Published online September 2014:409. doi:10.2147/DMSO.S51301

Mascarenhas-Melo F, Marado D, Palavra F, et al. Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women. Cardiovasc Diabetol. 2013;12(1):61. doi:10.1186/1475-2840-12-61

Rossi MC, Cristofaro MR, Gentile S, et al. Sex Disparities in the Quality of Diabetes Care: Biological and Cultural Factors May Play a Different Role for Different Outcomes: A cross-sectional observational study from the AMD Annals initiative. Diabetes Care. 2013;36(10):3162-3168. doi:10.2337/dc13-0184

Sattar N. Gender aspects in type 2 diabetes mellitus and cardiometabolic risk. Best Pract Res Clin Endocrinol Metab. 2013;27(4):501-507. doi:10.1016/j.beem.2013.05.006

Lyons MR, Peterson LR, McGill JB, et al. Impact of sex on the heart’s metabolic and functional responses to diabetic therapies. Am J Physiol Circ Physiol. 2013;305(11):H1584-H1591. doi:10.1152/ajpheart.00420.2013

Peterson LR, Saeed IM, McGill JB, et al. Sex and Type 2 Diabetes: Obesity-Independent Effects on Left Ventricular Substrate Metabolism and Relaxation in Humans. Obesity. 2012;20(4):802-810. doi:10.1038/oby.2011.208

Nadal-Casellas A, Proenza AM, Lladó I, Gianotti M. Sex-dependent differences in rat hepatic lipid accumulation and insulin sensitivity in response to diet-induced obesity. Biochem Cell Biol. 2012;90(2):164-172. doi:10.1139/o11-069

Høeg LD, Sjøberg KA, Jeppesen J, et al. Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling. Diabetes. 2011;60(1):64-73. doi:10.2337/db10-0698

Logue J, Walker JJ, Colhoun HM, et al. Do men develop type 2 diabetes at lower body mass indices than women? Diabetologia. 2011;54(12):3003-3006. doi:10.1007/s00125-011-2313-3

Yang W, Lu J, Weng J, et al. Prevalence of Diabetes among Men and Women in China. N Engl J Med. 2010;362(12):1090-1101. doi:10.1056/NEJMoa0908292

Geer EB, Shen W. Gender differences in insulin resistance, body composition, and energy balance. Gend Med. 2009;6:60-75. doi:10.1016/j.genm.2009.02.002

Macotela Y, Boucher J, Tran TT, Kahn CR. Sex and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism. Diabetes. 2009;58(4):803-812. doi:10.2337/db08-1054

Perreault L, Ma Y, Dagogo-Jack S, et al. Sex Differences in Diabetes Risk and the Effect of Intensive Lifestyle Modification in the Diabetes Prevention Program. Diabetes Care. 2008;31(7):1416-1421. doi:10.2337/dc07-2390

Gregg EW, Gu Q, Cheng YJ, Venkat Narayan KM, Cowie CC. Mortality Trends in Men and Women with Diabetes, 1971 to 2000. Ann Intern Med. 2007;147(3):149. doi:10.7326/0003-4819-147-3-200708070-00167

Steinberg HO, Paradisi G, Cronin J, et al. Type II Diabetes Abrogates Sex Differences in Endothelial Function in Premenopausal Women. Circulation. 2000;101(17):2040-2046. doi:10.1161/01.CIR.101.17.2040

Metabolismo

Ciampolillo Anna. Metabolic syndrome and gut microbiota: there is a gender difference? Ital J Gender-Specific Med. 2019;5(1):21-26. doi:10.1723/3148.31295

Xu YXZ, Ande SR, Mishra S. Gonadectomy in Mito-Ob mice revealed a sex-dimorphic relationship between prohibitin and sex steroids in adipose tissue biology and glucose homeostasis. Biol Sex Differ. 2018;9(1):37. doi:10.1186/s13293-018-0196-4

Tao Z, Zheng LD, Smith C, et al. Estradiol signaling mediates gender difference in visceral adiposity via autophagy. Cell Death Dis. 2018;9(3):309. doi:10.1038/s41419-018-0372-9

Chang E, Varghese M, Singer K. Gender and Sex Differences in Adipose Tissue. Curr Diab Rep. 2018;18(9):69. doi:10.1007/s11892-018-1031-3

Valencak TG, Osterrieder A, Schulz TJ. Sex matters: The effects of biological sex on adipose tissue biology and energy metabolism. Redox Biol. 2017;12:806-813. doi:10.1016/j.redox.2017.04.012

Link JC, Reue K. Genetic Basis for Sex Differences in Obesity and Lipid Metabolism. Annu Rev Nutr. 2017;37(1):225-245. doi:10.1146/annurev-nutr-071816-064827

White UA, Tchoukalova YD. Sex dimorphism and depot differences in adipose tissue function. Biochim Biophys Acta - Mol Basis Dis. 2014;1842(3):377-392. doi:10.1016/j.bbadis.2013.05.006

Kanter R, Caballero B. Global Gender Disparities in Obesity: A Review. Adv Nutr. 2012;3(4):491-498. doi:10.3945/an.112.002063

Kautzky-Willer A, Handisurya A. Metabolic diseases and associated complications: sex and gender matter! Eur J Clin Invest. 2009;39(8):631-648. doi:10.1111/j.1365-2362.2009.02161.x

Lovejoy JC, Sainsbury A. Sex differences in obesity and the regulation of energy homeostasis. Obes Rev. 2009;10(2):154-167. doi:10.1111/j.1467-789X.2008.00529.x

Recettori per estrogeni

Fuentes N, Silveyra P. Estrogen receptor signaling mechanisms. In: Adv Protein Chem Struct Biol. ; 2019:135-170. doi:10.1016/bs.apcsb.2019.01.001

Mahmoodzadeh S, Dworatzek E. The Role of 17β-Estradiol and Estrogen Receptors in Regulation of Ca2+ Channels and Mitochondrial Function in Cardiomyocytes. Front Endocrinol (Lausanne). 2019;10. doi:10.3389/fendo.2019.00310

Vona R, Gambardella L, Ortona E, et al. Functional Estrogen Receptors of Red Blood Cells. Do They Influence Intracellular Signaling? Cell Physiol Biochem. 2019;53(1):186-199. doi:10.33594/000000129

Banerjee S, Chambliss KL, Mineo C, Shaul PW. Recent insights into non-nuclear actions of estrogen receptor alpha. Steroids. 2014;81:64-69. doi:10.1016/j.steroids.2013.11.002

Farmacologia

Christopoulou F, Tran TT, Sahu SK, Miwa M, Ananiadou S. Adverse drug events and medication relation extraction in electronic health records with ensemble deep learning methods. J Am Med Informatics Assoc. 2020;27(1):39-46. doi:10.1093/jamia/ocz101

Bots SH, Groepenhoff F, Eikendal ALM, Tannenbaum C, Rochon PA, Regitz-Zagrosek V, Miller VM, Day D, Asselbergs FW, den Ruijter HM. Adverse Drug Reactions to Guideline-Recommended Heart Failure Drugs in Women: A Systematic Review of the Literature. JACC Heart Fail. 2019 Mar;7(3):258-266. doi: 10.1016/j.jchf.2019.01.009. PMID: 30819382.

Bots SH, Groepenhoff F, Eikendal ALM, Tannenbaum C, Rochon PA, Regitz-Zagrosek V, Miller VM, Day D, Asselbergs FW, den Ruijter HM. Adverse Drug Reactions to Guideline-Recommended Heart Failure Drugs in Women: A Systematic Review of the Literature. JACC Heart Fail. 2019 Mar;7(3):258-266. doi: 10.1016/j.jchf.2019.01.009. PMID: 30819382.

Meiners B, Shenoy C, Zordoky BN. Clinical and preclinical evidence of sex-related differences in anthracycline-induced cardiotoxicity. Biol Sex Differ. 2018;9(1):38. doi:10.1186/s13293-018-0198-2

Tamargo J, Rosano G, Walther T, et al. Gender differences in the effects of cardiovascular drugs. Eur Hear J - Cardiovasc Pharmacother. 2017;3(3):163-182. doi:10.1093/ehjcvp/pvw042

Pershina, Pakhomova, Widera, et al. Gender Differences in the Pharmacological Actions of Pegylated Glucagon-Like Peptide-1 on Endothelial Progenitor Cells and Angiogenic Precursor Cells in a Combination of Metabolic Disorders and Lung Emphysema. Int J Mol Sci. 2019;20(21):5414. doi:10.3390/ijms20215414

Overholser BR, Kays MB, Lagvankar S, Goldman M, Mueller BA, Sowinski KM. Pharmacokinetics of Intravenously Administered Levofloxacin in Men and Women. Pharmacotherapy. 2005;25(10):1310-1318. doi:10.1592/phco.2005.25.10.1310

Kim DK, Kim JH, Lee JY, et al. Reappraisal of the treatment duration of antibiotic regimens for acute uncomplicated cystitis in adult women: a systematic review and network meta-analysis of 61 randomised clinical trials. Lancet Infect Dis. 2020;20(9):1080-1088. doi:10.1016/S1473-3099(20)30121-3

Banerjee S, Chambliss KL, Mineo C, Shaul PW. Recent insights into non-nuclear actions of estrogen receptor alpha. Steroids. 2014;81:64-69. doi:10.1016/j.steroids.2013.11.002

Cadeddu Dessalvi C, Pepe A, Penna C, et al. Sex differences in anthracycline-induced cardiotoxicity: the benefits of estrogens. Heart Fail Rev. 2019;24(6):915-925. doi:10.1007/s10741-019-09820-2

Zucker I, Prendergast BJ. Sex differences in pharmacokinetics predict adverse drug reactions in women. Biol Sex Differ. 2020;11(1):32. doi:10.1186/s13293-020-00308-5

van Reekum EA, Rosic T, Hudson J, et al. Social functioning outcomes in men and women receiving medication-assisted treatment for opioid use disorder. Biol Sex Differ. 2020;11(1):20. doi:10.1186/s13293-020-00298-4

Klein SL, Morgan R. The impact of sex and gender on immunotherapy outcomes. Biol Sex Differ. 2020;11(1):24. doi:10.1186/s13293-020-00301-y

Bitto A, Ito TK, Pineda V V, et al. Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. Elife. 2016;5. doi:10.7554/eLife.16351

Chowdhury R, Khan H, Heydon E, et al. Adherence to cardiovascular therapy: a meta-analysis of prevalence and clinical consequences. Eur Heart J. 2013;34(38):2940-2948. doi:10.1093/eurheartj/eht295

Fitofarmaci

Campesi, Romani, Franconi. The Sex–Gender Effects in the Road to Tailored Botanicals. Nutrients. 2019;11(7):1637. doi:10.3390/nu11071637

Recettori per estrogeni

Mahmoodzadeh S, Dworatzek E. The Role of 17β-Estradiol and Estrogen Receptors in Regulation of Ca2+ Channels and Mitochondrial Function in Cardiomyocytes. Front Endocrinol (Lausanne). 2019;10. doi:10.3389/fendo.2019.00310

Fuentes N, Silveyra P. Estrogen receptor signaling mechanisms. In: Adv Protein Chem Struct Biol. ; 2019:135-170. doi:10.1016/bs.apcsb.2019.01.001

Vona R, Gambardella L, Ortona E, et al. Functional Estrogen Receptors of Red Blood Cells. Do They Influence Intracellular Signaling? Cell Physiol Biochem. 2019;53(1):186-199. doi:10.33594/000000129

Banerjee S, Chambliss KL, Mineo C, Shaul PW. Recent insights into non-nuclear actions of estrogen receptor alpha. Steroids. 2014;81:64-69. doi:10.1016/j.steroids.2013.11.002

Fattori di rischio

Fumo di sigaretta

Puente D., et al.  The role of gender in a smoking cessation intervention: a cluster randomized clinical trial   BMC Public Health 2011, 11:369

Grotvedt L, Stigum H, Hovengen R, Graff-Iversen S. Social differences in smoking and snuff use among Norwegian adolescents: A population based survey. BMC Public Health. 2008;8(1):322. doi:10.1186/1471-2458-8-322

Vollmer WM, Enright PL, Pedula KL, et al. Race and Gender Differences in the Effects of Smoking on Lung Function. Chest. 2000;117(3):764-772. doi:10.1378/chest.117.3.764

Fisiopatologia

Bianconi E, Casadei R, Frabetti F, Ventura C, Facchin F, Canaider S. Sex-Specific Transcriptome Differences in Human Adipose Mesenchymal Stem Cells. Genes (Basel). 2020;11(8):909. doi:10.3390/genes11080909

Olney KC, Brotman SM, Andrews JP, Valverde-Vesling VA, Wilson MA. Reference genome and transcriptome informed by the sex chromosome complement of the sample increase ability to detect sex differences in gene expression from RNA-Seq data. Biol Sex Differ. 2020;11(1):42. doi:10.1186/s13293-020-00312-9

Greco EA, Lenzi A, Migliaccio S, Gessani S. Epigenetic Modifications Induced by Nutrients in Early Life Phases: Gender Differences in Metabolic Alteration in Adulthood. Front Genet. 2019;10. doi:10.3389/fgene.2019.00795

Della Torre S, Maggi A. Sex Differences: A Resultant of an Evolutionary Pressure? Cell Metab. 2017;25(3):499-505. doi:10.1016/j.cmet.2017.01.006

Regitz‐Zagrosek V. Sex and gender differences in health. EMBO Rep. 2012;13(7):596-603. doi:10.1038/embor.2012.87

SNC e SNP

 

Immunologia

Klein SL, Morgan R. The impact of sex and gender on immunotherapy outcomes. Biol Sex Differ. 2020;11(1):24. doi:10.1186/s13293-020-00301-y

Morgan CP, Bale TL. Sex differences in microRNA regulation of gene expression: no smoke, just miRs. Biol Sex Differ. 2012;3(1):22. doi:10.1186/2042-6410-3-22

Autoimmunità

Qing Chen, Wenxin Zhang, Neeti Sadana and Xinzhong Chen Estrogen receptors in pain modulation: cellular signaling  Biology of Sex Differences 2021 https://doi.org/10.1186/s13293-021-00364-5

Lasrado N, Jia T, Massilamany C, Franco R, Illes Z, Reddy J. Mechanisms of sex hormones in autoimmunity: focus on EAE. Biol Sex Differ. 2020;11(1):50. doi:10.1186/s13293-020-00325-4

Laganà B, Zullo A, Scribano ML, et al. Sex Differences in Response to TNF-Inhibiting Drugs in Patients With Spondyloarthropathies or Inflammatory Bowel Diseases. Front Pharmacol. 2019;10. doi:10.3389/fphar.2019.00047

Avila M, Bansal A, Culberson J, Peiris AN. The Role of Sex Hormones in Multiple Sclerosis. Eur Neurol. 2018;80(1-2):93-99. doi:10.1159/000494262

Dupuis ML, Conti F, Maselli A, et al. The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis. Front Immunol. 2018;9. doi:10.3389/fimmu.2018.01903

Tedeschi SK, Bermas B, Costenbader KH. Sexual disparities in the incidence and course of SLE and RA. Clin Immunol. 2013;149(2):211-218. doi:10.1016/j.clim.2013.03.003

Tiniakou E, Costenbader KH, Kriegel MA. Sex-specific environmental influences on the development of autoimmune diseases. Clin Immunol. 2013;149(2):182-191. doi:10.1016/j.clim.2013.02.011

González DA, Díaz BB, Rodríguez Pérez M del C, Hernández AG, Chico BND, de León AC. Sex hormones and autoimmunity. Immunol Lett. 2010;133(1):6-13. doi:10.1016/j.imlet.2010.07.001

Immunità anti-infettiva

Jones BG, Sealy RE, Penkert RR, et al. From Influenza Virus Infections to Lupus: Synchronous Estrogen Receptor α and RNA Polymerase II Binding Within the Immunoglobulin Heavy Chain Locus. Viral Immunol. 2020;33(4):307-315. doi:10.1089/vim.2019.0144

Vom Steeg LG, Flores-Garcia Y, Zavala F, Klein SL. Irradiated sporozoite vaccination induces sex-specific immune responses and protection against malaria in mice. Vaccine. 2019;37(32):4468-4476. doi:10.1016/j.vaccine.2019.06.075

Ruggieri A, Gagliardi MC, Anticoli S. Sex-Dependent Outcome of Hepatitis B and C Viruses Infections: Synergy of Sex Hormones and Immune Responses? Front Immunol. 2018;9. doi:10.3389/fimmu.2018.02302

Ghosh S, Klein RS. Sex Drives Dimorphic Immune Responses to Viral Infections. J Immunol. 2017;198(5):1782-1790. doi:10.4049/jimmunol.1601166

Ingersoll MA. Sex differences shape the response to infectious diseases. Kline KA, ed. PLOS Pathog. 2017;13(12):e1006688. doi:10.1371/journal.ppat.1006688

Muenchhoff M, Goulder PJR. Sex Differences in Pediatric Infectious Diseases. J Infect Dis. 2014;209(suppl 3):S120-S126. doi:10.1093/infdis/jiu232

Sistema immunitario

Shang D, Wang L, Klionsky DJ, Cheng H, Zhou R. Sex differences in autophagy-mediated diseases: toward precision medicine. Autophagy. Published online 17 April 2020:1-12. doi:10.1080/15548627.2020.1752511

Jaillon S, Berthenet K, Garlanda C. Sexual Dimorphism in Innate Immunity. Clin Rev Allergy Immunol. 2019;56(3):308-321. doi:10.1007/s12016-017-8648-x

Gal-Oz ST, Maier B, Yoshida H, et al. ImmGen report: sexual dimorphism in the immune system transcriptome. Nat Commun. 2019;10(1):4295. doi:10.1038/s41467-019-12348-6

Ortona E, Pierdominici M, Rider V. Editorial: Sex Hormones and Gender Differences in Immune Responses. Front Immunol. 2019;10. doi:10.3389/fimmu.2019.01076

Elderman M, Hugenholtz F, Belzer C, et al. Sex and strain dependent differences in mucosal immunology and microbiota composition in mice. Biol Sex Differ. 2018;9(1):26. doi:10.1186/s13293-018-0186-6

Bernin H, Fehling H, Marggraff C, Tannich E, Lotter H. The cytokine profile of human NKT cells and PBMCs is dependent on donor sex and stimulus. Med Microbiol Immunol. 2016;205(4):321-332. doi:10.1007/s00430-016-0449-y

Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016;16(10):626-638. doi:10.1038/nri.2016.90

Pinheiro I, Dejager L, Libert C. X-chromosome-located microRNAs in immunity: Might they explain male/female differences? BioEssays. 2011;33(11):791-802. doi:10.1002/bies.201100047

Libert C, Dejager L, Pinheiro I. The X chromosome in immune functions: when a chromosome makes the difference. Nat Rev Immunol. 2010;10(8):594-604. doi:10.1038/nri2815

Bouman A, Heineman MJ, Faas MM. Sex hormones and the immune response in humans. Hum Reprod Update. 2005;11(4):411-423. doi:10.1093/humupd/dmi008

Indicatori socio-economico-culturali di genere

Karen M, Piroska Ö, Claudia G-M, Gerry E. WHO | Gender equality, work and health: A review of the evidence. WHO. Published online 2019. Accessed January 15, 2021. http://www.who.int/occupational_health/publications/genderwork/en/

Giannico OV, Ambrosino I, Patano F, Germinario C, Quarto M, Moretti AM. Educational level, marital status and sex as social gender discharge determinants in chronic obstructive pulmonary disease exacerbations: a time-to-event analysis. Monaldi Arch Chest Dis. 2019;89(2). doi:10.4081/monaldi.2019.1017

Carrieri V, Jones AM. Inequality of opportunity in health: A decomposition-based approach. Health Econ. 2018;27(12):1981-1995. doi:10.1002/hec.3814

Escolar-Pujolar A, Córdoba Doña JA, Goicolea Julían I, et al. El efecto del estado civil sobre las desigualdades sociales y de género en la mortalidad por diabetes mellitus en Andalucía. Endocrinol Diabetes y Nutr. 2018;65(1):21-29. doi:10.1016/j.endinu.2017.10.006

Zajacova A, Huzurbazar S, Todd M. Gender and the structure of self-rated health across the adult life span. Soc Sci Med. 2017;187:58-66. doi:10.1016/j.socscimed.2017.06.019

Chylińska J, Łazarewicz M, Rzadkiewicz M, et al. The role of gender in the active attitude toward treatment and health among older patients in primary health care—self-assessed health status and sociodemographic factors as moderators. BMC Geriatr. 2017;17(1):284. doi:10.1186/s12877-017-0677-z

Stringhini S, Carmeli C, Jokela M, et al. Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women. Lancet. 2017;389(10075):1229-1237. doi:10.1016/S0140-6736(16)32380-7

Legato MJ, Johnson PA, Manson JE. Consideration of Sex Differences in Medicine to Improve Health Care and Patient Outcomes. JAMA. 2016;316(18):1865. doi:10.1001/jama.2016.13995

Solé-Auró A, Alcañiz M. Educational attainment, gender and health inequalities among older adults in Catalonia (Spain). Int J Equity Health. 2016;15(1):126. doi:10.1186/s12939-016-0414-9

Chetty R, Stepner M, Abraham S, et al. The Association Between Income and Life Expectancy in the United States, 2001-2014. JAMA. 2016;315(16):1750-1766. doi:10.1001/jama.2016.4226

Caroli E, Weber-Baghdiguian L. Self-reported health and gender: The role of social norms. Soc Sci Med. 2016;153:220-229. doi:10.1016/j.socscimed.2016.02.023

Katikireddi SV. Economic opportunity: a determinant of health? Lancet Public Heal. 2016;1(1):e4-e5. doi:10.1016/S2468-2667(16)30004-4

Mackenbach JP, Kulhánová I, Artnik B, et al. Changes in mortality inequalities over two decades: register based study of European countries. BMJ. Published online April 11, 2016:i1732. doi:10.1136/bmj.i1732

Boerma T, Hosseinpoor AR, Verdes E, Chatterji S. A global assessment of the gender gap in self-reported health with survey data from 59 countries. BMC Public Health. 2016;16(1):675. doi:10.1186/s12889-016-3352-y

Hosseinpoor AR, Bergen N, Mendis S, et al. Socioeconomic inequality in the prevalence of noncommunicable diseases in low- and middle-income countries: Results from the World Health Survey. BMC Public Health. 2012;12(1):474. doi:10.1186/1471-2458-12-474

WHO (World Health Organization). Improving Equity in Health by Addressing Social Determinants Edited by: The Commission on Social Determinants of Health Knowledge Networks, Jennifer H. Lee and Ritu Sadana.; 2011. Accessed January 15, 2021. https://apps.who.int/iris/bitstream/handle/10665/44793/9789241503037_eng.pdf;jsessionid=635E04F7DEC0C86A5CCBDFF6C5BCF1EC?sequence=1

Bambra C, Pope D, Swami V, et al. Gender, health inequalities and welfare state regimes: a cross-national study of 13 European countries. J Epidemiol Community Heal. 2009;63(1):38-44. doi:10.1136/jech.2007.070292

Marmot M, Friel S, Bell R, Houweling TA, Taylor S. Closing the gap in a generation: health equity through action on the social determinants of health. Lancet. 2008;372(9650):1661-1669. doi:10.1016/S0140-6736(08)61690-6

Eikemo TA, Bambra C, Joyce K, Dahl E. Welfare state regimes and income-related health inequalities: a comparison of 23 European countries. Eur J Public Health. 2008;18(6):593-599. doi:10.1093/eurpub/ckn092

Artazcoz L, Borrell C, Cortas I, Escriba-Aguir V, Cascant L. Occupational epidemiology and work related inequalities in health: a gender perspective for two complementary approaches to work and health research. J Epidemiol Community Heal. 2007;61(Supplement 2):ii39-ii45. doi:10.1136/jech.2007.059774

Lande RG, Marin BA, Chang AS, Lande GR. Gender differences and alcohol use in the US Army. J Am Osteopath Assoc. 2007;107(9):401-407. http://www.ncbi.nlm.nih.gov/pubmed/17908832

Rieker PP, Bird CE. Rethinking Gender Differences in Health: Why We Need to Integrate Social and Biological Perspectives. Journals Gerontol Ser B. 2005;60(Special_Issue_2):S40-S47. doi:10.1093/geronb/60.Special_Issue_2.S40

Emslie C, Hunt K, Macintyre S. Gender differences in minor morbidity among full time employees of a British university. J Epidemiol Community Heal. 1999;53(8):465-475. doi:10.1136/jech.53.8.465

Infettivologia

Santinelli L, Ceccarelli G, Borrazzo C, et al. Sex-related differences in markers of immune activation in virologically suppressed HIV-infected patients. Biol Sex Differ. 2020;11(1):23. doi:10.1186/s13293-020-00302-x

Vázquez-Martínez ER, García-Gómez E, Camacho-Arroyo I, González-Pedrajo B. Sexual dimorphism in bacterial infections. Biol Sex Differ. 2018;9(1):27. doi:10.1186/s13293-018-0187-5

Celestino I, Checconi P, Amatore D, et al. Differential Redox State Contributes to Sex Disparities in the Response to Influenza Virus Infection in Male and Female Mice. Front Immunol. 2018;9. doi:10.3389/fimmu.2018.01747

Reardon S. Infections reveal inequality between the sexes. Nature. 2016;534(7608):447-447. doi:10.1038/534447a

Úbeda F, Jansen VAA. The evolution of sex-specific virulence in infectious diseases. Nat Commun. 2016;7(1):13849. doi:10.1038/ncomms13849

Bellia G, Colombo D, Chimenti S, et al. Prevalence of acute and chronic viral seropositivity and characteristics of disease in patients with psoriatic arthritis treated with cyclosporine: a post hoc analysis from a sex point of view on the observational study of infectious events in psoriasis c. Clin Cosmet Investig Dermatol. Published online December 2015:1. doi:10.2147/CCID.S88306

Humphreys H, Fitzpatick F, Harvey BJ. Gender Differences in Rates of Carriage and Bloodstream Infection Caused by Methicillin-Resistant Staphylococcus aureus : Are They Real, Do They Matter and Why? Goldstein EJC, ed. Clin Infect Dis. Published online 22 July 2015:civ576. doi:10.1093/cid/civ576

Rhines AS. The role of sex differences in the prevalence and transmission of tuberculosis. Tuberculosis. 2013;93(1):104-107. doi:10.1016/j.tube.2012.10.012

World Health Organization RO for the WP. Taking sex and gender into account in emerging infectious disease programme : an analytical framework. In: Manila : WHO Regional Office for the Western Pacific; 2011:80.WHO

Invecchiamento e longevità - Fragilità

Zhang J, Xu L, Sun L, Li J, Qin W. Gender difference in the association of frailty and health care utilization among Chinese older adults: results from a population-based study. Aging Clin Exp Res. 2020;32(10):1985-1991. doi:10.1007/s40520-019-01410-4

Roman Lay AA, Ferreira do Nascimento C, Caba Burgos F, et al. Gender Differences between Multimorbidity and All-Cause Mortality among Older Adults. Curr Gerontol Geriatr Res. 2020;2020:1-7. doi:10.1155/2020/7816785

Kiely KM, Brady B, Byles J. Gender, mental health and ageing. Maturitas. 2019;129:76-84. doi:10.1016/j.maturitas.2019.09.004

Chen P-L, Tsai Y-L, Lin M-H, Wang J. Gender differences in health promotion behaviors and quality of life among community-dwelling elderly. J Women Aging. 2018;30(3):259-274. doi:10.1080/08952841.2017.1301170

Marais GAB, Gaillard J-M, Vieira C, et al. Sex gap in aging and longevity: can sex chromosomes play a role? Biol Sex Differ. 2018;9(1):33. doi:10.1186/s13293-018-0181-y

Chylińska J, Łazarewicz M, Rzadkiewicz M, et al. The role of gender in the active attitude toward treatment and health among older patients in primary health care—self-assessed health status and sociodemographic factors as moderators. BMC Geriatr. 2017;17(1):284. doi:10.1186/s12877-017-0677-z

Gordon EH, Peel NM, Samanta M, Theou O, Howlett SE, Hubbard RE. Sex differences in frailty: A systematic review and meta-analysis. Exp Gerontol. 2017;89:30-40. doi:10.1016/j.exger.2016.12.021

Ostan R, Monti D, Gueresi P, Bussolotto M, Franceschi C, Baggio G. Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine. Clin Sci. 2016;130(19):1711-1725. doi:10.1042/CS20160004

Machiela MJ, Zhou W, Karlins E, et al. Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome. Nat Commun. 2016;7(1):11843. doi:10.1038/ncomms11843

Oksuzyan A, Juel K, Vaupel JW, Christensen K. Men: good health and high mortality. Sex differences in health and aging. Aging Clin Exp Res. 2008;20(2):91-102. doi:10.1007/BF03324754

Ipertensione arteriosa

Philbois S V., Facioli TP, Gastaldi AC, et al. Important differences between hypertensive middle-aged women and men in cardiovascular autonomic control—a critical appraisal. Biol Sex Differ. 2021;12(1):11. doi:10.1186/s13293-020-00355-y

Kane AE, Howlett SE. Differences in Cardiovascular Aging in Men and Women. In: ; 2018:389-411. doi:10.1007/978-3-319-77932-4_25

Leadership

Grinnell M, Higgins S, Yost K, et al. The proportion of male and female editors in women’s health journals: A critical analysis and review of the sex gap,. Int J Women’s Dermatology. 2020;6(1):7-12. doi:10.1016/j.ijwd.2019.11.005

Mahmood SN, Blanco I. The road to equity for women in academic rheumatology. Nat Rev Rheumatol. 2020;16(12):669-670. doi:10.1038/s41584-020-00517-7

Richter KP, Clark L, Wick JA, et al. Women Physicians and Promotion in Academic Medicine. N Engl J Med. 2020;383(22):2148-2157. doi:10.1056/nejmsa1916935

Hamulyák EN, Brockmeier AJ, Killas JD, Ananiadou S, Middeldorp S, Leroi AM. Women’s health in The BMJ : a data science history. BMJ Open. 2020;10(10):e039759. doi:10.1136/bmjopen-2020-039759

Kalaitzi S, Czabanowska K, Azzopardi-Muscat N, et al. Women, healthcare leadership and societal culture: a qualitative study. J Healthc Leadersh. 2019;Volume 11:43-59. doi:10.2147/JHL.S194733

Cushman M. Diversity and inclusion in a new medical journal: Advancing science in the 21st century. Res Pract Thromb Haemost. 2018;2(4):620-621. doi:10.1002/rth2.12154

Di Nuovo F, Onorati M, Nicola M, Cassoni M. Il valore aggiunto della differenza di genere nelle professioni sanitarie. Ital J Gender-Specific Med. Published online 2018:34-36.:Fulltext

Bismark M, Morris J, Thomas L, Loh E, Phelps G, Dickinson H. Reasons and remedies for under-representation of women in medical leadership roles: a qualitative study from Australia. BMJ Open. 2015;5(11):e009384-e009384. doi:10.1136/bmjopen-2015-009384

Angell M. Shattering the Glass Ceiling. JAMA Intern Med. 2014;174(4):635. doi:10.1001/jamainternmed.2013.13918

Amrein K, Langmann A, Fahrleitner-Pammer A, Pieber TR, Zollner-Schwetz I. Women Underrepresented on Editorial Boards of 60 Major Medical Journals. Gend Med. 2011;8(6):378-387. doi:10.1016/j.genm.2011.10.007

Sidhu R, Rajashekhar P, Lavin VL, et al. The gender imbalance in academic medicine: a study of female authorship in the United Kingdom. J R Soc Med. 2009;102(8):337-342. doi:10.1258/jrsm.2009.080378

Medicina dello sport

Post EG, Biese KM, Schaefer DA, et al. Sport-Specific Associations of Specialization and Sex With Overuse Injury in Youth Athletes. Sport Heal A Multidiscip Approach. 2020;12(1):36-42. doi:10.1177/1941738119886855

O’Connor D, Gardner L, Larkin P, Pope A, Williams AM. Positive youth development and gender differences in high performance sport. J Sports Sci. 2020;38(11-12):1399-1407. doi:10.1080/02640414.2019.1698001

Mohr M, Skoradal M-B, Andersen TR, Krustrup P. Gender-dependent evaluation of football as medicine for prediabetes. Eur J Appl Physiol. 2019;119(9):2011-2024. doi:10.1007/s00421-019-04188-5

Tannenbaum C, Bekker S. Sex, gender, and sports. BMJ. Published online 20 March 2019:l1120. doi:10.1136/bmj.l1120

Barriopedro M, López de Subijana C, Muniesa C. Insights into life after sport for Spanish Olympians: Gender and career path perspectives. Müller J, ed. PLoS One. 2018;13(12):e0209433. doi:10.1371/journal.pone.0209433

Tomschi F, Bloch W, Grau M. Impact of Type of Sport, Gender and Age on Red Blood Cell Deformability of Elite Athletes. Int J Sports Med. 2018;39(01):12-20. doi:10.1055/s-0043-119879

Natali S, Ferioli D, La Torre A, Bonato M. Physical and technical demands of elite beach volleyball according to playing position and gender. J Sports Med Phys Fitness. 2018;59(1). doi:10.23736/S0022-4707.17.07972-5

Zvan M, Zenic N, Sekulic D, Cubela M, Lesnik B. Gender- and Sport-Specific Associations Between Religiousness and Doping Behavior in High-Level Team Sports. J Relig Health. 2017;56(4):1348-1360. doi:10.1007/s10943-016-0254-3

Waddington GS. Gender differences in athlete ECGs. J Sci Med Sport. 2017;20(4):317. doi:10.1016/j.jsams.2017.03.001

Brown WJ, Mielke GI, Kolbe-Alexander TL. Gender equality in sport for improved public health. Lancet. 2016;388(10051):1257-1258. doi:10.1016/S0140-6736(16)30881-9

Molanorouzi K, Khoo S, Morris T. Motives for adult participation in physical activity: type of activity, age, and gender. BMC Public Health. 2015;15(1):66. doi:10.1186/s12889-015-1429-7

Theberge N. Studying gender and injuries: a comparative analysis of the literatures on women’s injuries in sport and work. Ergonomics. 2012;55(2):183-193. doi:10.1080/00140139.2011.592602

Neurologia

Demenze e Malattia di Alzheimer

Ambrosino I, Vacante M, Politi C, Barbagelata E, Ciarambino T. Sexual differences regarding Alzheimer’s disease: a narrative review. J Gerontol Geriatr. 2020;68(3):168-173. doi:10.36150/2499-6564-376

Sundermann EE, Panizzon MS, Chen X, Andrews M, Galasko D, Banks SJ. Sex differences in Alzheimer’s-related Tau biomarkers and a mediating effect of testosterone. Biol Sex Differ. 2020;11(1):33. doi:10.1186/s13293-020-00310-x

Liu C-C, Li C-Y, Sun Y, Hu SC. Gender and Age Differences and the Trend in the Incidence and Prevalence of Dementia and Alzheimer’s Disease in Taiwan: A 7-Year National Population-Based Study. Biomed Res Int. 2019;2019:1-12. doi:10.1155/2019/5378540

Rahman A, Jackson H, Hristov H, et al. Sex and Gender Driven Modifiers of Alzheimer’s: The Role for Estrogenic Control Across Age, Race, Medical, and Lifestyle Risks. Front Aging Neurosci. 2019;11. doi:10.3389/fnagi.2019.00315

Congdon EE. Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer’s Disease. Front Neurosci. 2018;12. doi:10.3389/fnins.2018.00372

Rocca WA, Mielke MM, Vemuri P, Miller VM. Sex and gender differences in the causes of dementia: A narrative review. Maturitas. 2014;79(2):196-201. doi:10.1016/j.maturitas.2014.05.008

Mielke M, Vemuri P, Rocca W. Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences. Clin Epidemiol. Published online January 2014:37. doi:10.2147/CLEP.S37929

Li R, Cui J, Shen Y. Brain sex matters: Estrogen in cognition and Alzheimer’s disease. Mol Cell Endocrinol. 2014;389(1-2):13-21. doi:10.1016/j.mce.2013.12.018

Miech RA, Breitner JCS, Zandi PP, Khachaturian AS, Anthony JC, Mayer L. Incidence of AD may decline in the early 90s for men, later for women. Neurology. 2002;58(2):209-218. doi:10.1212/WNL.58.2.209

Gao S, Hendrie HC, Hall KS, Hui S. The Relationships Between Age, Sex, and the Incidence of Dementia and Alzheimer Disease. Arch Gen Psychiatry. 1998;55(9):809. doi:10.1001/archpsyc.55.9.809

Fratiglioni L, Viitanen M, von Strauss E, Tontodonati V, Herlitz A, Winblad B. Very Old Women at Highest Risk of Dementia and Alzheimer’s Disease: Incidence Data from the Kungsholmen Project, Stockholm. Neurology. 1997;48(1):132-138. doi:10.1212/WNL.48.1.132

Ictus ischemico

Gocan S, Fitzpatrick T, Wang CQ, et al. Diagnosis of Transient Ischemic Attack. Stroke. 2020;51(11):3371-3374. doi:10.1161/STROKEAHA.120.031510

Strong B, Lisabeth LD, Reeves M. Sex differences in IV thrombolysis treatment for acute ischemic stroke. Neurology. 2020;95(1):e11-e22. doi:10.1212/WNL.0000000000009733

Wang X, Carcel C, Wang R, et al. Worse prognosis in women, compared with men, after thrombolysis: An individual patient data pooling study of Asian acute stroke registries. Int J Stroke. Published online 8 July 2020:174749302093830. doi:10.1177/1747493020938307

Sclerosi multipla

Voskuhl RR, Patel K, Paul F, et al. Sex differences in brain atrophy in multiple sclerosis. Biol Sex Differ. 2020;11(1):49. doi:10.1186/s13293-020-00326-3

Altro

Hein M, Lanquart J-P, Loas G, Hubain P, Linkowski P. Alterations of neural network organization during REM sleep in women: implication for sex differences in vulnerability to mood disorders. Biol Sex Differ. 2020;11(1):22. doi:10.1186/s13293-020-00297-5

Abi-Ghanem C, Robison LS, Zuloaga KL. Androgens’ effects on cerebrovascular function in health and disease. Biol Sex Differ. 2020;11(1):35. doi:10.1186/s13293-020-00309-4

Duong P, Tenkorang MAA, Trieu J, McCuiston C, Rybalchenko N, Cunningham RL. Neuroprotective and neurotoxic outcomes of androgens and estrogens in an oxidative stress environment. Biol Sex Differ. 2020;11(1):12. doi:10.1186/s13293-020-0283-1

Arnold AP. Sexual differentiation of brain and other tissues: Five questions for the next 50 years. Horm Behav. 2020;120:104691. doi:10.1016/j.yhbeh.2020.104691

Caslin B, Maguire C, Karmakar A, Mohler K, Wylie D, Melamed E. Alcohol shifts gut microbial networks and ameliorates a murine model of neuroinflammation in a sex-specific pattern. Proc Natl Acad Sci. 2019;116(51):25808-25815. doi:10.1073/pnas.1912359116

Giedd JN, Raznahan A, Mills KL, Lenroot RK. Review: magnetic resonance imaging of male/female differences in human adolescent brain anatomy. Biol Sex Differ. 2012;3(1):19. doi:10.1186/2042-6410-3-19

Guma E, Devenyi GA, Malla A, Shah J, Chakravarty MM, Pruessner M. Neuroanatomical and Symptomatic Sex Differences in Individuals at Clinical High Risk for Psychosis. Front Psychiatry. 2017 Dec 22;8:291. doi: 10.3389/fpsyt.2017.00291. PMID: 29312018; PMCID: PMC5744013.

Odontostomatologia

Valerio MS, Basilakos DS, Kirkpatrick JE, et al. Sex-based differential regulation of bacterial-induced bone resorption. J Periodontal Res. 2017;52(3):377-387. doi:10.1111/jre.12401

Rathod KS, Kapil V, Velmurugan S, et al. Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans. J Clin Invest. 2016;127(1):169-182. doi:10.1172/JCI89429

Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016;16(10):626-638. doi:10.1038/nri.2016.90

Fischer J, Jung N, Robinson N, Lehmann C. Sex differences in immune responses to infectious diseases. Infection. 2015;43(4):399-403. doi:10.1007/s15010-015-0791-9

Zenobia C, Luo XL, Hashim A, et al. Commensal bacteria-dependent select expression of CXCL2 contributes to periodontal tissue homeostasis. Cell Microbiol. 2013;15(8):1419-1426. doi:10.1111/cmi.12127

Graves DT, Oates T, Garlet GP. Review of osteoimmunology and the host response in endodontic and periodontal lesions. J Oral Microbiol. 2011;3(1):5304. doi:10.3402/jom.v3i0.5304

Shiau HJ, Reynolds MA. Sex Differences in Destructive Periodontal Disease: Exploring the Biologic Basis. J Periodontol. 2010;81(11):1505-1517. doi:10.1902/jop.2010.100045

Shiau HJ, Reynolds MA. Sex Differences in Destructive Periodontal Disease: Exploring the Biologic Basis. J Periodontol. 2010;81(11):1505-1517. doi:10.1902/jop.2010.100045

Rettew JA, Marriott I, Huet YM. Sex Differences in Innate Immune Responses to Bacterial Pathogens. In: Sex Hormones and Immunity to Infection. Springer Berlin Heidelberg; 2010:123-146. doi:10.1007/978-3-642-02155-8_5

Rettew JA, Huet-Hudson YM, Marriott I. Testosterone Reduces Macrophage Expression in the Mouse of Toll-Like Receptor 4, a Trigger for Inflammation and Innate Immunity. Biol Reprod. 2008;78(3):432-437. doi:10.1095/biolreprod.107.063545

Silva TA, Garlet GP, Fukada SY, Silva JS, Cunha FQ. Chemokines in Oral Inflammatory Diseases: Apical Periodontitis and Periodontal Disease. J Dent Res. 2007;86(4):306-319. doi:10.1177/154405910708600403

Garlet GP, Martins W, Fonseca BAL, Ferreira BR, Silva JS. Matrix metalloproteinases, their physiological inhibitors and osteoclast factors are differentially regulated by the cytokine profile in human periodontal disease. J Clin Periodontol. 2004;31(8):671-679. doi:10.1111/j.1600-051X.2004.00545.x

Oncologia

Wagner AD, Oertelt-Prigione S, Adjei A, et al. Gender medicine and oncology: report and consensus of an ESMO workshop. Ann Oncol. 2019;30(12):1914-1924. doi:10.1093/annonc/mdz414

Apparato Digerente

Clausen F, Behrens H-M, Krüger S, Röcken C. Sexual dimorphism in gastric cancer: tumor-associated neutrophils predict patient outcome only for women. J Cancer Res Clin Oncol. 2020;146(1):53-66. doi:10.1007/s00432-019-03082-z

Muscogiuri G, Altieri B, Albertelli M, et al. Epidemiology of pancreatic neuroendocrine neoplasms: a gender perspective. Endocrine. 2020;69(2):441-450. doi:10.1007/s12020-020-02331-3

Phipps M, Livanos A, Guo A, et al. Gender Matters: Characteristics of Hepatocellular Carcinoma in Women From a Large, Multicenter Study in the United States. Am J Gastroenterol. 2020;115(9):1486-1495. doi:10.14309/ajg.0000000000000643

Lopes-Ramos CM, Kuijjer ML, Ogino S, et al. Correction: Gene Regulatory Network Analysis Identifies Sex-Linked Differences in Colon Cancer Drug Metabolism. Cancer Res. 2019;79(8):2084-2084. doi:10.1158/0008-5472.CAN-19-0678

Lemke M, DeWit Y, Nanji S, Booth CM, Flemming JA. The role of sex in the outcomes of patients with biliary tract cancers remains unclear: A population-based study. Am J Surg. 2018;216(6):1118-1121. doi:10.1016/j.amjsurg.2018.05.021

Nipp R, Tramontano AC, Kong CY, et al. Disparities in cancer outcomes across age, sex, and race/ethnicity among patients with pancreatic cancer. Cancer Med. 2018;7(2):525-535. doi:10.1002/cam4.1277

Etxeberria J, Goicoa T, López-Abente G, Riebler A, Ugarte MD. Spatial gender-age-period-cohort analysis of pancreatic cancer mortality in Spain (1990–2013). Meliker J, ed. PLoS One. 2017;12(2):e0169751. doi:10.1371/journal.pone.0169751

Yang Y, Wang G, He J, et al. Gender differences in colorectal cancer survival: A meta-analysis. Int J Cancer. 2017;141(10):1942-1949. doi:10.1002/ijc.30827

Garufi C, Giacomini E, Torsello A, et al. Gender effects of single nucleotide polymorphisms and miRNAs targeting clock-genes in metastatic colorectal cancer patients (mCRC). Sci Rep. 2016;6(1):34006. doi:10.1038/srep34006

Apparato Respiratorio

Vargas AJ, Harris CC. Biomarker development in the precision medicine era: lung cancer as a case study. Nat Rev Cancer. 2016;16(8):525-537. doi:10.1038/nrc.2016.56

Melanoma

Gibney GT, Atkins MB. Choice of first‐line therapy in metastatic melanoma. Cancer. 2019;125(5):666-669. doi:10.1002/cncr.31774

Duma N, Abdel‐Ghani A, Yadav S, et al. Sex Differences in Tolerability to Anti‐Programmed Cell Death Protein 1 Therapy in Patients with Metastatic Melanoma and Non‐Small Cell Lung Cancer: Are We All Equal? Oncologist. 2019;24(11). doi:10.1634/theoncologist.2019-0094

Marzagalli M, Montagnani Marelli M, Casati L, Fontana F, Moretti RM, Limonta P. Estrogen Receptor β in Melanoma: From Molecular Insights to Potential Clinical Utility. Front Endocrinol (Lausanne). 2016;7. doi:10.3389/fendo.2016.00140

Gupta S, Artomov M, Goggins W, Daly M, Tsao H. Gender Disparity and Mutation Burden in Metastatic Melanoma. J Natl Cancer Inst. 2015;107(11):djv221. doi:10.1093/jnci/djv221

Dronca RS, Dong H. A Gender Factor in Shaping T-Cell Immunity to Melanoma. Front Oncol. 2015;5. doi:10.3389/fonc.2015.00008

Sistema Nervoso

Sun T, Plutynski A, Ward S, Rubin JB. An integrative view on sex differences in brain tumors. Cell Mol Life Sci. 2015;72(17):3323-3342. doi:10.1007/s00018-015-1930-2

Glioblastoma

Qu C, Ma J, Zhang Y, et al. Estrogen receptor variant ER-α36 promotes tamoxifen agonist activity in glioblastoma cells. Cancer Sci. 2019;110(1):221-234. doi:10.1111/cas.13868

Yang W, Warrington NM, Taylor SJ, et al. Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data. Sci Transl Med. 2019;11(473):eaao5253. doi:10.1126/scitranslmed.aao5253

Tumori dell'Osso

Jawad MU, Cheung MC, Min ES, Schneiderbauer MM, Koniaris LG, Scully SP. Ewing sarcoma demonstrates racial disparities in incidence-related and sex-related differences in outcome. Cancer. 2009;115(15):3526-3536. doi:10.1002/cncr.24388

Tumori della Tiroide

Jawad MU, Cheung MC, Min ES, Schneiderbauer MM, Koniaris LG, Scully SP. Ewing sarcoma demonstrates racial disparities in incidence-related and sex-related differences in outcome. Cancer. 2009;115(15):3526-3536. doi:10.1002/cncr.24388

Tumori della mammella

Jawad MU, Cheung MC, Min ES, Schneiderbauer MM, Koniaris LG, Scully SP. Ewing sarcoma demonstrates racial disparities in incidence-related and sex-related differences in outcome. Cancer. 2009;115(15):3526-3536. doi:10.1002/cncr.24388

Tumori delle Cellule del Sangue

Cicconi L, Platzbecker U, Avvisati G, et al. Long-term results of all-trans retinoic acid and arsenic trioxide in non-high-risk acute promyelocytic leukemia: update of the APL0406 Italian-German randomized trial. Leukemia. 2020;34(3):914-918. doi:10.1038/s41375-019-0589-3

Lin S, Liu Y, Goldin LR, et al. Sex-related DNA methylation differences in B cell chronic lymphocytic leukemia. Biol Sex Differ. 2019;10(1):2. doi:10.1186/s13293-018-0213-7

Lo-Coco F, Avvisati G, Vignetti M, et al. Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia. N Engl J Med. 2013;369(2):111-121. doi:10.1056/NEJMoa1300874

Tumori dell'Apparato Urinario

Shi J, Wen Z, Zhong G, et al. Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2. Science (80- ). 2020;368(6494):1016-1020. doi:10.1126/science.abb7015

Terapia

Wagner AD. Sex differences in cancer chemotherapy effects, and why we need to reconsider BSA-based dosing of chemotherapy. ESMO Open. 2020;5(5):e000770. doi:10.1136/esmoopen-2020-000770

Kroemer G, Zitvogel L. The breakthrough of the microbiota. Nat Rev Immunol. 2018;18(2):87-88. doi:10.1038/nri.2018.4

Conforti F, Pala L, Bagnardi V, et al. Cancer immunotherapy efficacy and patients’ sex: a systematic review and meta-analysis. Lancet Oncol. 2018;19(6):737-746. doi:10.1016/S1470-2045(18)30261-4

Grassadonia A, Sperduti I, Vici P, et al. Effect of Gender on the Outcome of Patients Receiving Immune Checkpoint Inhibitors for Advanced Cancer: A Systematic Review and Meta-Analysis of Phase III Randomized Clinical Trials. J Clin Med. 2018;7(12):542. doi:10.3390/jcm7120542

Capone I, Marchetti P, Ascierto PA, Malorni W, Gabriele L. Sexual Dimorphism of Immune Responses: A New Perspective in Cancer Immunotherapy. Front Immunol. 2018;9. doi:10.3389/fimmu.2018.00552

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Epidemiologia

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Altro

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Pediatria

Cowell W, Colicino E, Askowitz T, Nentin F, Wright RJ. Fetal sex and maternal postpartum depressive symptoms: findings from two prospective pregnancy cohorts. Biol Sex Differ. 2021;12(1):6. doi:10.1186/s13293-020-00348-x

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Galjaard S, Ameye L, Lees CC, et al. Sex differences in fetal growth and immediate birth outcomes in a low-risk Caucasian population. Biol Sex Differ. 2019;10(1):48. doi:10.1186/s13293-019-0261-7

Nguyen L, Castro O, De Dios R, Sandoval J, McKenna S, Wright CJ. Sex-differences in LPS-induced neonatal lung injury. Sci Rep. 2019;9(1):8514. doi:10.1038/s41598-019-44955-0

Maxeiner S, Sester M, Krasteva-Christ G. Novel human sex-typing strategies based on the autism candidate gene NLGN4X and its male-specific gametologue NLGN4Y. Biol Sex Differ. 2019;10(1):62. doi:10.1186/s13293-019-0279-x

Okyar A, Kumar SA, Filipski E, et al. Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling. Sci Rep. 2019;9(1):10505. doi:10.1038/s41598-019-46977-0

Psichiatria

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Ansia e insonnia

Bigalke JA, Greenlund IM, Carter JR. Sex differences in self-report anxiety and sleep quality during COVID-19 stay-at-home orders. Biol Sex Differ. 2020;11(1):56. doi:10.1186/s13293-020-00333-4

Depressione

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Disforia di Genere

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Manzouri A, Savic I. Possible Neurobiological Underpinnings of Homosexuality and Gender Dysphoria. Cereb Cortex. 2019;29(5):2084-2101. doi:10.1093/cercor/bhy090

Kilpatrick LA, Holmberg M, Manzouri A, Savic I. Cross sex hormone treatment is linked with a reversal of cerebral patterns associated with gender dysphoria to the baseline of cisgender controls. Eur J Neurosci. 2019;50(8):3269-3281. doi:10.1111/ejn.14420

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Case LK, Brang D, Landazuri R, Viswanathan P, Ramachandran VS. Altered White Matter and Sensory Response to Bodily Sensation in Female-to-Male Transgender Individuals. Arch Sex Behav. 2017;46(5):1223-1237. doi:10.1007/s10508-016-0850-z

Feusner JD, Dervisic J, Kosidou K, Dhejne C, Bookheimer S, Savic I. Female-to-Male Transsexual Individuals Demonstrate Different Own Body Identification. Arch Sex Behav. 2016;45(3):525-536. doi:10.1007/s10508-015-0596-z

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Schizofrenia

Bigalke JA, Greenlund IM, Carter JR. Sex differences in self-report anxiety and sleep quality during COVID-19 stay-at-home orders. Biol Sex Differ. 2020;11(1):56. doi:10.1186/s13293-020-00333-4

Psicologia

Punzi L, Chia M, Cipolletta S, et al. The role of architectural design for rheumatic patients’ wellbeing: the point of view of Environmental Psychology. Reumatismo. 2020;72(1):60-66. doi:10.4081/reumatismo.2020.1251

Pazzaglia F, Moè A, Cipolletta S, et al. Multiple Dimensions of Self-Esteem and Their Relationship with Health in Adolescence. Int J Environ Res Public Health. 2020;17(8):2616. doi:10.3390/ijerph17082616

Galozzi P, Maghini I, Bakdounes L, et al. Prevalence of low back pain and its effect on health-related quality of life in 409 scholar adolescents from the Veneto region. Reumatismo. 2019;71(3):132-140. doi:10.4081/reumatismo.2019.1229

Reumatologia

Luger T, Seibt R, Rieger MA, Steinhilber B. Sex differences in muscle activity and motor variability in response to a non-fatiguing repetitive screwing task. Biol Sex Differ. 2020;11(1):6. doi:10.1186/s13293-020-0282-2

Rosa-Caldwell ME, Greene NP. Muscle metabolism and atrophy: let’s talk about sex. Biol Sex Differ. 2019;10(1):43. doi:10.1186/s13293-019-0257-3

Alwhaibi M, AlRuthia Y, Meraya AM. Gender Differences in the Prevalence of Complementary and Alternative Medicine Utilization among Adults with Arthritis in the United States. Evidence-Based Complement Altern Med. 2019;2019:1-11. doi:10.1155/2019/8739170

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Artrite Reumatoide

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Ricerca

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Kopel J, Perisetti A, Roghani A, Aziz M, Gajendran M, Goyal H. Racial and Gender-Based Differences in COVID-19. Front Public Heal. 2020;8. doi:10.3389/fpubh.2020.00418

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Comorbilità

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Epidemiologia

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Gravidanza

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Immunologia

Takahashi T, Iwasaki A. Sex differences in immune responses. Science (80- ). 2021;371(6527):347-348. doi:10.1126/science.abe7199

Brodin P. Immune determinants of COVID-19 disease presentation and severity. Nat Med. 2021;27(1):28-33. doi:10.1038/s41591-020-01202-8

Qiao Y, Wang X-M, Mannan R, et al. Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2. Proc Natl Acad Sci. 2021;118(1):e2021450118. doi:10.1073/pnas.2021450118

Bozgeyik I. Therapeutic potential of miRNAs targeting SARS-CoV-2 host cell receptor ACE2. Meta Gene. 2021;27:100831. doi:10.1016/j.mgene.2020.100831

Klein SL, Pekosz A, Park HS, et al. Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population. medRxiv. Published online 28 June 2020:2020.06.26.20139063. doi:10.1101/2020.06.26.20139063

Takahashi T, Ellingson MK, Wong P, et al. Sex differences in immune responses that underlie COVID-19 disease outcomes. Nature. 2020;588(7837):315-320. doi:10.1038/s41586-020-2700-3

Peng Y, Mentzer A, Liu G, et al. Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients. bioRxiv Prepr Serv Biol. Published online 8 June 2020:2020.06.05.134551. doi:10.1101/2020.06.05.134551

Long QX, Liu BZ, Deng HJ, et al. Antibody responses to SARS-CoV-2 in patients with COVID-19. Nat Med. 2020;26(6):845-848. doi:10.1038/s41591-020-0897-1

Gagliardi MC, Tieri P, Ortona E, Ruggieri A. ACE2 expression and sex disparity in COVID-19. Cell Death Discov. 2020;6(1):37. doi:10.1038/s41420-020-0276-1

Tadiri CP, Gisinger T, Kautzy-Willer A, et al. The influence of sex and gender domains on COVID-19 cases and mortality. Can Med Assoc J. 2020;192(36):E1041-E1045. doi:10.1503/cmaj.200971

Haitao T, Vermunt J V., Abeykoon J, et al. COVID-19 and Sex Differences. Mayo Clin Proc. 2020;95(10):2189-2203. doi:10.1016/j.mayocp.2020.07.024

Stopsack KH, Mucci LA, Antonarakis ES, Nelson PS, Kantoff PW. TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention? Cancer Discov. 2020;10(6):779-782. doi:10.1158/2159-8290.CD-20-0451

Asselta R, Paraboschi EM, Mantovani A, Duga S. ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy. medRxiv. Published online 11 April 2020:2020.03.30.20047878. doi:10.1101/2020.03.30.20047878

Cai G. Bulk and Single-Cell Transcriptomics Identify Tobacco-Use Disparity in Lung Gene Expression of ACE2, the Receptor of 2019-nCov. medRxiv. Published online 28 February 2020:2020.02.05.20020107. doi:10.1101/2020.02.05.20020107

Mauvais-Jarvis F, Klein SL, Levin ER. Estradiol, Progesterone, Immunomodulation, and COVID-19 Outcomes. Endocrinology. 2020;161(9). doi:10.1210/endocr/bqaa127

Lieberman NAP, Peddu V, Xie H, et al. In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age. Cadwell K, ed. PLOS Biol. 2020;18(9):e3000849. doi:10.1371/journal.pbio.3000849

Zeng F, Dai C, Cai P, et al. A comparison study of SARS‐CoV‐2 IgG antibody between male and female COVID‐19 patients: A possible reason underlying different outcome between sex. J Med Virol. 2020;92(10):2050-2054. doi:10.1002/jmv.25989

Foresta C, Rocca MS, Di Nisio A. Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome. J Endocrinol Invest. Published online 16 September 2020. doi:10.1007/s40618-020-01383-6

Xudong X, Junzhu C, Xingxiang W, Furong Z, Yanrong L. Age- and gender-related difference of ACE2 expression in rat lung. Life Sci. 2006;78(19):2166-2171. doi:10.1016/j.lfs.2005.09.038

Medicina del lavoro

INAIL. Scheda nazionale infortuni COVID-19. I dati sulle denunce da Covid-19 (monitoraggio al 15 giugno 2020). INAIL. Published 2020.Monitoraggio al 15 giugno 2020 INAIL

Pediatria

Sun D, Li H, Lu X-X, et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J Pediatr. 2020;16(3):251-259. doi:10.1007/s12519-020-00354-4

Radiologia

Xie X, Zhong Z, Zhao W, Zheng C, Wang F, Liu J. Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing. Radiology. 2020;296(2):E41-E45. doi:10.1148/radiol.2020200343

Poggiali E, Dacrema A, Bastoni D, et al. Can Lung US Help Critical Care Clinicians in the Early Diagnosis of Novel Coronavirus (COVID-19) Pneumonia? Radiology. 2020;295(3):E6-E6. doi:10.1148/radiol.2020200847

Bai HX, Hsieh B, Xiong Z, et al. Performance of Radiologists in Differentiating COVID-19 from Non-COVID-19 Viral Pneumonia at Chest CT. Radiology. 2020;296(2):E46-E54. doi:10.1148/radiol.2020200823

Borghesi A, Zigliani A, Masciullo R, et al. Radiographic severity index in COVID-19 pneumonia: relationship to age and sex in 783 Italian patients. Radiol Med. 2020;125(5):461-464. doi:10.1007/s11547-020-01202-1

Boraschi P. COVID-19 Pulmonary Involvement: Is Really an Interstitial Pneumonia? Acad Radiol. 2020;27(6):900. doi:10.1016/j.acra.2020.04.010

Yasukawa K, Minami T. Point-of-Care Lung Ultrasound Findings in Patients with COVID-19 Pneumonia. Am J Trop Med Hyg. 2020;102(6):1198-1202. doi:10.4269/ajtmh.20-0280

Hani C, Trieu NH, Saab I, et al. COVID-19 pneumonia: A review of typical CT findings and differential diagnosis. Diagn Interv Imaging. 2020;101(5):263-268. doi:10.1016/j.diii.2020.03.014

Zhang W. Imaging changes in severe COVID-19 pneumonia. Intensive Care Med. 2020;46(4):583-585. doi:10.1007/s00134-020-05976-w

Cleverley J, Piper J, Jones MM. The role of chest radiography in confirming covid-19 pneumonia. BMJ. Published online 16 July 2020:m2426. doi:10.1136/bmj.m2426

Lyu P, Liu X, Zhang R, Shi L, Gao J. The performance of chest CT in evaluating the clinical severity of COVID-19 pneumonia. Invest Radiol. 2020;Publish Ah. doi:10.1097/RLI.0000000000000689

Ding X, Xu J, Zhou J, Long Q. Chest CT findings of COVID-19 pneumonia by duration of symptoms. Eur J Radiol. 2020;127:109009. doi:10.1016/j.ejrad.2020.109009

Guillo E, Bedmar Gomez I, Dangeard S, et al. COVID-19 pneumonia: Diagnostic and prognostic role of CT based on a retrospective analysis of 214 consecutive patients from Paris, France. Eur J Radiol. 2020;131:109209. doi:10.1016/j.ejrad.2020.109209

Ufuk F. Three-dimensional CT of COVID-19 Pneumonia. Radiology. 2020;296(3):E180-E180. doi:10.1148/radiol.2020201183

Terapia

Salton F, Confalonieri P, Meduri GU, et al. Prolonged Low-Dose Methylprednisolone in Patients With Severe COVID-19 Pneumonia. Open Forum Infect Dis. 2020;7(10). doi:10.1093/ofid/ofaa421

Battaglini D, Robba C, Ball L, et al. Emerging therapies for COVID-19 pneumonia. Expert Opin Investig Drugs. 2020;29(7):633-637. doi:10.1080/13543784.2020.1771694

Benucci M, Giannasi G, Cecchini P, et al. COVID‐19 pneumonia treated with Sarilumab: A clinical series of eight patients. J Med Virol. 2020;92(11):2368-2370. doi:10.1002/jmv.26062

Cantini F, Niccoli L, Nannini C, et al. Beneficial impact of Baricitinib in COVID-19 moderate pneumonia; multicentre study. J Infect. 2020;81(4):647-679. doi:10.1016/j.jinf.2020.06.052

Di Stadio A, Della Volpe A, Ralli M, Ricci G. Gender differences in COVID-19 infection. The estrogen effect on upper and lower airways. Can it help to figure out a treatment? Eur Rev Med Pharmacol Sci. 2020;24(10):5195-5196. doi:10.26355/eurrev_202005_21298

Ambrosino I, Barbagelata E, Corbi G, Ciarambino T, Politi C, Moretti AM. Gender differences in treatment of Coronavirus Disease-2019. Monaldi Arch Chest Dis. 2020;90(4). doi:10.4081/monaldi.2020.1508

Tumori

Montopoli M, Zumerle S, Vettor R, et al. Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532). Ann Oncol. 2020;31(8):1040-1045. doi:10.1016/j.annonc.2020.04.479

Vaccini

Baden LR, El Sahly HM, Essink B, et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. N Engl J Med. 2021;384(5):403-416. doi:10.1056/NEJMoa2035389

Voysey M, Costa Clemens SA, Madhi SA, et al. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. Lancet. 2021;397(10277):881-891. doi:10.1016/S0140-6736(21)00432-3

Ciarambino T, Barbagelata E, Corbi G, et al. Gender differences in vaccine therapy: where are we in COVID-19 pandemic? Monaldi Arch Chest Dis. Published online April 8, 2021. doi:10.4081/monaldi.2021.1669

Voysey M, Costa Clemens SA, Madhi SA, et al. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. Lancet. 2021;397(10277):881-891. doi:10.1016/S0140-6736(21)00432-3

Baden LR, El Sahly HM, Essink B, et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. N Engl J Med. 2021;384(5):403-416. doi:10.1056/NEJMoa2035389

Polack FP, Thomas SJ, Kitchin N, et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med. 2020;383(27):2603-2615. doi:10.1056/NEJMoa2034577

Pagano MT, Peruzzu D, Ruggieri A, Ortona E, Gagliardi MC. Vitamin D and Sex Differences in COVID-19. Front Endocrinol (Lausanne). 2020;11. doi:10.3389/fendo.2020.567824

Bastard P, Rosen LB, Zhang Q, et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science (80- ). 2020;370(6515):eabd4585. doi:10.1126/science.abd4585

No-Covid

Liang W, Guan W, Chen R, et al. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020;21(3):335-337. doi:10.1016/S1470-2045(20)30096-6

De Rosa S, Spaccarotella C, Basso C, et al. Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era. Eur Heart J. 2020;41(22):2083-2088. doi:10.1093/eurheartj/ehaa409

Martini N, Piccinni C, Pedrini A, Maggioni A. CoViD-19 e malattie croniche: conoscenze attuali, passi futuri e il progetto MaCroScopio. Recent Prog Med. 2020;111:198-201. doi:http://dx.doi.org/10.1701/3347.33180

Altro

Shi J, Wen Z, Zhong G, et al. Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2. Science (80- ). 2020;368(6494):1016-1020. doi:10.1126/science.abb7015

Sicurezza stradale

Lombardi DA, Horrey WJ, Courtney TK. Age-related differences in fatal intersection crashes in the United States. Accid Anal Prev. 2017;99:20-29. doi:10.1016/j.aap.2016.10.030

Shen S, Neyens DM. The effects of age, gender, and crash types on drivers’ injury-related health care costs. Accid Anal Prev. 2015;77:82-90. doi:10.1016/j.aap.2015.01.014

Amarasingha N, Dissanayake S. Gender differences of young drivers on injury severity outcome of highway crashes. J Safety Res. 2014;49:113.e1-120. doi:10.1016/j.jsr.2014.03.004

Santamariña-Rubio E, Pérez K, Olabarria M, Novoa AM. Gender differences in road traffic injury rate using time travelled as a measure of exposure. Accid Anal Prev. 2014;65:1-7. doi:10.1016/j.aap.2013.11.015

Obeng K. Gender differences in injury severity risks in crashes at signalized intersections. Accid Anal Prev. 2011;43(4):1521-1531. doi:10.1016/j.aap.2011.03.004

Morgan A, Mannering FL. The effects of road-surface conditions, age, and gender on driver-injury severities. Accid Anal Prev. 2011;43(5):1852-1863. doi:10.1016/j.aap.2011.04.024

Islam S, Mannering F. Driver aging and its effect on male and female single-vehicle accident injuries: Some additional evidence. J Safety Res. 2006;37(3):267-276. doi:10.1016/j.jsr.2006.04.003

Vaccini

Aaby P, Benn CS, Flanagan KL, et al. The non-specific and sex-differential effects of vaccines. Nat Rev Immunol. 2020;20(8):464-470. doi:10.1038/s41577-020-0338-x

Potluri T, Fink AL, Sylvia KE, et al. Age-associated changes in the impact of sex steroids on influenza vaccine responses in males and females. npj Vaccines. 2019;4(1):29. doi:10.1038/s41541-019-0124-6

Hoes J, Knol MJ, Mollema L, Buisman A, de Melker HE, van der Klis FRM. Comparison of antibody response between boys and girls after infant and childhood vaccinations in the Netherlands. Vaccine. 2019;37(32):4504-4510. doi:10.1016/j.vaccine.2019.06.055

Fischinger S, Boudreau CM, Butler AL, Streeck H, Alter G. Sex differences in vaccine-induced humoral immunity. Semin Immunopathol. 2019;41(2):239-249. doi:10.1007/s00281-018-0726-5

Arsenović-Ranin N, Petrović R, Živković I, Bufan B, Stoiljković V, Leposavić G. Influence of aging on germinal centre reaction and antibody response to inactivated influenza virus antigens in mice: sex-based differences. Biogerontology. 2019;20(4):475-496. doi:10.1007/s10522-019-09811-8

Boef AGC, van der Klis FRM, Berbers GAM, et al. Differences by sex in IgG levels following infant and childhood vaccinations: An individual participant data meta-analysis of vaccination studies. Vaccine. 2018;36(3):400-407. doi:10.1016/j.vaccine.2017.11.070

Fink AL, Engle K, Ursin RL, Tang W-Y, Klein SL. Biological sex affects vaccine efficacy and protection against influenza in mice. Proc Natl Acad Sci. 2018;115(49):12477-12482. doi:10.1073/pnas.1805268115

Poland GA, Ovsyannikova IG, Kennedy RB. Personalized vaccinology: A review. Vaccine. 2018;36(36):5350-5357. doi:10.1016/j.vaccine.2017.07.062

Flanagan KL, Fink AL, Plebanski M, Klein SL. Sex and Gender Differences in the Outcomes of Vaccination over the Life Course. Annu Rev Cell Dev Biol. 2017;33(1):577-599. doi:10.1146/annurev-cellbio-100616-060718

Ruggieri A, Anticoli S, D’Ambrosio A, Giordani L, Viora M. The influence of sex and gender on immunity, infection and vaccination. Ann Ist Super Sanita. 2016;52(2):198-204. doi:https://doi.org/10.4415/ann_16_02_11

Baynam G, Zhang G, Khoo S-K, et al. Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses. Vaccine. 2008;26(29-30):3574-3579. doi:10.1016/j.vaccine.2008.05.011

Engler RJM. Half- vs Full-Dose Trivalent Inactivated Influenza Vaccine (2004-2005). Arch Intern Med. 2008;168(22):2405. doi:10.1001/archinternmed.2008.513

Vitamina D

Dupuis, M.L., Pagano, M.T., Pierdominici, M. et al. The role of vitamin D in autoimmune diseases: could sex make the difference?. Biol Sex Differ 12, 12 (2021). doi:10.1186/s13293-021-00358-3

Sabetta JR, DePetrillo P, Cipriani RJ, Smardin J, Burns LA, Landry ML. Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults. Goletti D, ed. PLoS One. 2010;5(6):e11088. doi:10.1371/journal.pone.0011088

Isaia G, Giorgino R, Rini GB, Bevilacqua M, Maugeri D, Adami S. Prevalence of hypovitaminosis D in elderly women in Italy: clinical consequences and risk factors. Osteoporos Int. 2003;14(7):577-582. doi:10.1007/s00198-003-1390-7

Scharla SH. Prevalence of Subclinical Vitamin D Deficiency in Different European Countries. Osteoporos Int. 1998;8(S2):S7-S12. doi:10.1007/PL00022726

Miscellanea

Garrido P, Tsang J, Peters S. Gender gap: surveying the world for tomorrow. ESMO Open. 2020;5(4):e000805. doi:10.1136/esmoopen-2020-000805

Shahid M. Addressing the Underrepresentation of Women in Cardiology through Tangible Opportunities for Mentorship and Leadership. Methodist Debakey Cardiovasc J. 2019;15(1):e1-e2. doi:10.14797/mdcj-15-1-e1

Rossi D, Bizzarro A, Affanni P, Pasquarella C, Odone A, Signorelli C. The educational background of the Top Managers of the Italian Health Authorities: Results of a study on eight Regions. Acta Biomed. 2019;90(9 S):87-91. doi:10.23750/abm.v90i9-S.8731

Jagsi R. Sexual Harassment in Medicine — #MeToo. N Engl J Med. 2018;378(3):209-211. doi:10.1056/NEJMp1715962

Blumenthal DM, Olenski AR, Yeh RW, et al. Sex Differences in Faculty Rank Among Academic Cardiologists in the United States. Circulation. 2017;135(6):506-517. doi:10.1161/CIRCULATIONAHA.116.023520

Yusuf S, Wittes J. Interpreting Geographic Variations in Results of Randomized, Controlled Trials. Drazen JM, Harrington DP, McMurray JJV, Ware JH, Woodcock J, eds. N Engl J Med. 2016;375(23):2263-2271. doi:10.1056/NEJMra1510065

Jagsi R, Griffith KA, Jones R, Perumalswami CR, Ubel P, Stewart A. Sexual Harassment and Discrimination Experiences of Academic Medical Faculty. JAMA. 2016;315(19):2120. doi:10.1001/jama.2016.2188

Furnas HJ, Johnson DJ, Bajaj AK, Kalliainen L, Rohrich RJ. Women and Men in Plastic Surgery. Plast Reconstr Surg. 2016;138(3):743-745. doi:10.1097/PRS.0000000000002513

Clayton JA. Studying both sexes: a guiding principle for biomedicine. FASEB J. 2016;30(2):519-524. doi:10.1096/fj.15-279554

Jagsi R, Biga C, Poppas A, et al. Work Activities and Compensation of Male and Female Cardiologists. J Am Coll Cardiol. 2016;67(5):529-541. doi:10.1016/j.jacc.2015.10.038

Legato MJ, Johnson PA, Manson JE. Consideration of Sex Differences in Medicine to Improve Health Care and Patient Outcomes. JAMA. 2016;316(18):1865. doi:10.1001/jama.2016.13995

Cifre E, Vera M, Signani F. Women and men at work: Analyzing occupational stress and well-being from a gender perspective. - PsycNET. Revista Puertorriqueña de Psicología. Published 2015. Accessed January 15, 2021. https://psycnet.apa.org/record/2016-04263-003

Jena AB, Khullar D, Ho O, Olenski AR, Blumenthal DM. Sex Differences in Academic Rank in US Medical Schools in 2014. JAMA. 2015;314(11):1149. doi:10.1001/jama.2015.10680

Wang Y, Hunt K, Nazareth I, Freemantle N, Petersen I. Do men consult less than women? An analysis of routinely collected UK general practice data. BMJ Open. 2013;3(8):e003320. doi:10.1136/bmjopen-2013-003320

Carr PL, Ash AS, Friedman RH, et al. Faculty Perceptions of Gender Discrimination and Sexual Harassment in Academic Medicine. Ann Intern Med. 2000;132(11):889. doi:10.7326/0003-4819-132-11-200006060-00007